'Competitive inhibition' diaporamas de présentation

Chapter 14

Chapter 14. Enzyme Kinetics to accompany Biochemistry, 2/e by Reginald Garrett and Charles Grisham.

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Enzyme Review

Enzyme Review. Lock and Key Model Induced Fit Model Inhibitors Competitive Inhibition Non- competetive Inhibition Activators. Inhibitors. Inhibitors. Inhibitors. Inhibitors. Inhibitors. Inhibitors. Inhibitors. Inhibitors. Inhibitors. Inhibitors. Inhibitors. Inhibitors.

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E nzyme inhibition Irreversible and reversible inhibition

E nzyme inhibition Irreversible and reversible inhibition * Irreversible : inhibitor becomes covalently bound to enzyme thereby diminishing its activity * Can be used for the elucidation of functional groups at the enzyme active site * group-specific reagents affinity labels

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MECHANISM OF EXCRETION

MECHANISM OF EXCRETION. RUBY.R FIRST YEAR M-PHARM PHARMACOLOGY. EXCRETION. Excretion is the passage out of systematically absorbed drug. Drugs are eliminated from the body either unchanged by the process of excretion or converted to Metabolites. Polar compounds more efficiently eliminated.

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CHEMISTRY IN EVERYDAY LIFE

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SURVEY OF BIOCHEMISTRY Enzyme Kinetics and Inhibition

SURVEY OF BIOCHEMISTRY Enzyme Kinetics and Inhibition. k. v = A P. Rates of Chemical Reactions. Enzyme kinetics is the study of rates of reactions catalyzed by enyzmes. The rxn rate (velocity, v) can be described in several ways: [1] disappearance of reactant, A

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Enzyme Kinetics II

Enzyme Kinetics II. 10/16/2008. Kinetic data cannot unambiguously establish a reaction mechanism. Although a phenomenological description can be obtained the nature of the reaction intermediates remain indeterminate and other independent measurements are needed .

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Competitive Inhibition

Competitive Inhibition. Competitive Inhibition. Uncompetitive Inhibition. Mixed Inhibition. Inhibiting a Carboxypeptidase. Carboxypeptidases bind peptides and cleave peptide bonds Design inhibitor that matches the active site. Inhibiting ACE. Complementary inhibitors Thiols are effective

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Chapter 5 Enzymes, Coenzyme and Energy

Chapter 5 Enzymes, Coenzyme and Energy. Biology 100 Spring 2009. Energy. All living things require energy. Nutrients are one source of energy, as well as being molecules organisms require to grow, reproduce or repair

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ENZYMES & Chemical Digestion

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Enzymes

Enzymes. Objectives: (a) explain that enzymes are globular proteins that catalyse metabolic reactions; (b) explain the mode of action of enzymes in terms of an active site, enzyme/substrate complex, lowering of activation energy and enzyme specificity; . Enzymes.

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Biochem (Test 1)

Biochem (Test 1). 11. Which of the following statements most directly supports the claim that different species of organisms use different metabolic strategies to meet their energy requirements for growth, reproduction, and homeostasis?.

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Enzymes

Enzymes. Large molecules made of various amino acids Act as catalysts to speed up reactions w/out being destroyed Highly specific Lowers energy of activation level. Enzymes lower the energy of activation for a reaction. Enzyme Kinetics. E + S ? ES complex ? E + P

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Enzyme Bead Simulation

Enzyme Bead Simulation. Enzyme -. Organic catalyst speeds up reactions proteins lower activation energy E a can be reused over and over. COENZYME - . 1/2 enzyme 1/2 vitamin enhance the effect of an enzyme. COOPERATIVE GROUP ROLES:. Recorder - writes down data Grabber - gets the beads

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Chapter 8 Metabolism

Chapter 8 Metabolism. Questions . How does 2 nd law of thermodynamics explain diffusion? What is a catabolic process? What is an anabolic process? Which, catabolic or anabolic, requires energy? Which, catabolic or anabolic, produces energy?. Questions (Answers) .

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7.6 Enzymes (AHL)

7.6 Enzymes (AHL). Pp 210 - 213. Pp 69 -71. M etabolic pathways . Metabolic reactions often occurs in small step reactions with a number of intermediate products in-between Metabolic reactions includes: Catabolic reactions such as respiration &

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Enzyme-substrate reaction Competitive inhibition Non-competitive inhibition Co-factor

Draw sketch graphs for enzyme activity with a competitive inhibitor present and for a non-competitive inhibitor present. A. B. C. D. Enzyme-substrate reaction Competitive inhibition Non-competitive inhibition Co-factor.

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Energy Flow in the Cell

Energy Flow in the Cell. What is energy?. Capacity to do work. 1. Kinetic Energy - energy of movement (e.g. light, heat, electricity, movement of large objects). 2. Potential Energy - stored energy (e.g. chemical energy in bonds of molecules,

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7.6 Enzymes (AHL)

7.6 Enzymes (AHL). Pp 210 - 213. Pp 69 -71. M etabolic pathways . Metabolic reactions often occurs in small step reactions with a number of intermediate products in-between Metabolic reactions includes: Catabolic reactions such as respiration &

332 views • 9 slides