Avastin Industry (Microvascular Complications of Diabetes) S
The entire market for microvascular complications of diabetes (MCD) diabetic nephropathy, retinopathy, and neuropathy is facing an extremely high level of unmet need across the 7MM (US, 5EU and Japan). Despite its enormous potential, the MCD market is facing the major global barrier in the sparsely populated pipeline. The diabetic retinopathy segment of the market has recently seen rapid uptake of novel anti-VEGF therapies and is experiencing a strong growth. On the other hand, the diabetic neuropathy and nephropathy segments face the barrier in and increasing number of generic competitors. Avastin (bevacizumab) is a recombinant humanized IgG1 mAb that specifically binds to VEGF-A, thereby preventing the interaction of VEGF-A with its receptors on the surface of endothelial cells. Through VEGF-A inhibition, Avastin inhibits angiogenesis, and is indicated for the adjunctive treatment of metastatic colorectal cancer as well as for other types of cancer.
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