'Covalent modification' diaporamas de présentation

Protein Structure and Function

Protein Structure and Function. CHAPTER3. Control of Protein Function. 3-0 Overview : Mechanisms of Regulation. Protein function in living cells is precisely regulated

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Regulation of Metabolism

Regulation of Metabolism. Rationale for Regulation. Biological Efficiency. Flexibility : adaptaton to dietary changes Need for biosynthetic products Control of pre-existing enzymes Modulation : biosynthesis only as fast as needs for macromolecular syntesis. Competing Reactions: Regulation.

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Chapter 15 Enzyme Regulation

Chapter 15 Enzyme Regulation. Outline. What factors influence enzymatic activity? What are the general features of allosteric regulation? Can allosteric regulation be explained by conformational changes in proteins? What kinds of covalent modification regulate the activity of enzymes?

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Identical Twins with Different Hair Color

Identical Twins with Different Hair Color. What is Epigenetics ?. C.H. Waddington coined the term epigenetics to mean above or in addition to genetics to explain differentiation. How do different adult stem cells know their fate? Myoblasts can only form muscle cells

1.01k views • 52 slides

Glycogen Metabolism

Glycogen Metabolism. Introduction. Storage Polysaccharides. Why Polysaccharides?. Rapid mobilization Support anaerobic metabolism Animals cannot convert fats to glucose precursors. Why Polymers?. Osmotic Problem!. Glycogen Metabolism. Glycogen Breakdown. Storage Tissues.

1.72k views • 48 slides

Enzyme Regulation

Enzyme Regulation. What you Need to Know. Understand the different ways that enzyme activity is regulated. What factors influence enzyme activity? General understanding of symmetry model versus sequential model of allosteric regulation

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Quiz #4/5

Quiz #4/5. Quiz #4/5. #4: Glycolysis (Tuesday, Feb 20 th ) #5: TCA cycle (Monday, Mar 5 th ) Pathways are in the books Quiz will have the entire pathway: All cofactors will be present Random intermediate and enzymes removed You fill in the missing names

939 views • 39 slides

Apple Experiment

Apple Experiment. Come down and get an apple and a slice of lemon. When you get back to your seat: 1. Take a big bite of your delicious apple. 2. Immediately squeeze lemon juice over the apple flesh that is now exposed from the bite.

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Regulatory strategies Attila Ambrus

Regulatory strategies Attila Ambrus. aspartate trans- carbamoylase. first step in pyrimidine biosynthesis. Es often must be regulated so that they function only at the right place and time. Regulation is essential for coordinating the complexity of biochemical processes in an organism.

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Bioenergetics and Biochemical Reaction Types

bioenergetics is the study of the balance between energy intake in the form of food and energy utilization by organisms for life-sustaining processes- tissue synthesis, osmoregulation, digestion, respiration, reproduction, locomotion, etc. Bioenergetics and Biochemical Reaction Types.

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ENZYMES

ENZYMES. MALIK ALQUB MD. PHD. Effect of [substrate] on R X Velocity. substrate. substrate. substrate. E. E. E. E. E. E. E. E. E. E. E. E. E. E. E. E. E. E. E. E. E. Effect of [substrate] on R X Velocity. substrate ? enzymzs. Saturation. Vmax. E. E. E. E. E. E.

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Regulation of metabolism on the cellular level

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CHMI 2227E Biochemistry I

CHMI 2227E Biochemistry I. Enzymes: Regulation. In any organism, enzymes are always kept in check so that their activity can match the needs of the cell: Enzymes can be activated: the reaction is stimulated to generate more product;

179 views • 17 slides

Glycolysis

Introduction of Glucose Metabolism Lecture-2. Glycolysis. Glycolysis. Glycolysis is the breakdown of glucose to : 1- Provide energy in the form of ATP (main function) 2- Provide intermediates for other metabolic pathways. It occurs in cytosols of all tissues

321 views • 16 slides

Glycolysis

Introduction of Glucose Metabolism Lecture-2. Glycolysis. Glycolysis. Glycolysis is the breakdown of glucose to : 1- Provide energy in the form of ATP (main function) 2- Provide intermediates for other metabolic pathways. It occurs in cytosols of all tissues

749 views • 16 slides

Glycolysis

Introduction of Glucose Metabolism Lecture-2. Glycolysis. Glycolysis. Glycolysis is the breakdown of glucose to : 1- Provide energy in the form of ATP (main function) 2- Provide intermediates for other metabolic pathways. It occurs in cytosols of all tissues

645 views • 16 slides

Km Measure of binding affinity (roughly) The lower the Km, the tighter the binding Vmax

Km Measure of binding affinity (roughly) The lower the Km, the tighter the binding Vmax Maximum rate of enzyme Determined by turnover number (k cat ). How best to calculate them?. Double-reciprocal plot (Lineweaver-Burk). Problems 7a-d,8a,b. Regulation. Regulation.

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Lecture 13

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I. Introduction to PTMs Protein Phosphorylation (Ser/Thr) Methods ?enrichment. Applications

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