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Sandro Mazzaferro Cattedra di Nefrologia I Facoltà Medicina e Chirurgia

Sandro Mazzaferro Cattedra di Nefrologia I Facoltà Medicina e Chirurgia

XV Riunione del GdS DDialisi Peritoneale Bari, 19-20 Febbraio 2010. Question Time 2: In DP più vantaggi con la vitamina D o i VDRAs?. Sandro Mazzaferro Cattedra di Nefrologia I Facoltà Medicina e Chirurgia “Sapienza” Università di Roma. Why active Vitamin D therapy in PD .

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Paricalcitol and calcitriol therapeutic effects, prospective comparison of adult hemodialysis patients

Paricalcitol and calcitriol therapeutic effects, prospective comparison of adult hemodialysis patients

This study aimed to compare the efficacy of a selective activator of the Vitamin D Receptor (VDR)\nparicalcitol with calcitriol, for the repression in terms of intact Parathyroid Hormone (iPTH) secretion. A\ncomparative study was undertaken in order to determine whether paricalcitol provides a therapeutic\nadvantage to calcitriol. The groups has formed adult hemodialysis individuals treated with dialysis\nsolution three times (4 hours, each seans) per week for 8 months with 1.25 mmol/L calcium (Ca)\nbicarbonate dialysate. Patients with iPTH levels over 400 pg/ml were treated with paricalcitol. In\naddition, their iPTH levels over 295 pg/ml were treated with calcitriol. The treatment was cut of both\nparicalcitol and calcitriol over CaxP > 65 and iPTH <295 pg/mL. The cure was regulated according to\nlevels iPTH in patients both paricalcitol and calcitirol. The application was a rule as particular\nposthemodialysis. The patients were administered intravenosus paricalcitol 5-10 mcq and calcitriol 1-2\nmcq as bolus. Diet restriction was referenced to reduce P levels. All the patients have been screened with\nparathyroid gland ultrasound and parathyroid scintigraphy. Compared to initial value we achieved\n39.3% reduction in the group 2 iPTH concentration (569 pg/mL to 345 pg/mL). On the other hand iPTH\nconcentration has been identified as 337 pg/mL initially while the mean value was 357 pg/mL at the study\nend of in the group1. In other words the mean average iPTH values is not reduced in group1. These\nresults between Group 1 and Group 2 was statistically significant. As a result paricalcitol much more\nrapidly and meaningful to reduced according to calcitriol of iPTH levels in serum. On the other hand we\nhave not found difference between two groups with minimal advers effect. \n

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