Dhfr - PowerPoint PPT Presentation

Amnon Kohen Department of Chemistry The University of Iowa

Protein dynamics and tunneling effects in the DHFR and TS catalysis. Amnon Kohen Department of Chemistry The University of Iowa. Overview. Background and experimental tools Dihydrofolate Reductase (DHFR) Dynamics-activity relationship Thymidylate Synthase (TS) Alternative TS (FDTS). E.

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1.35k views • 115 slides

Science 3 March 2000: RESEARCH ARTICLE Vol. 287 no. 5458 pp. 1615-1622

Science 3 March 2000: RESEARCH ARTICLE Vol. 287 no. 5458 pp. 1615-1622 The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution

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DHFR

Minipool (376 hORFs ). DHFR. Log2(methotrexate/DMSO). Log2(methotrexate signal intensity). Additional File 4.

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SycE

A). YopE 1-18. SycE. E18-DHFR. DHFR. p. YopE 1-52. E52-DHFR. p. DHFR. SycE. YopE 1-53. E53-DHFR. p. DHFR. SycE. YopE 1-138. E138-DHFR. DHFR. SycE. p. YopE 1-138 -DHFR. YopE 1-52 -DHFR. YopE 1-53 -DHFR. YopE 1-18 -DHFR. B). Control. YopE 1-138 -DHFR.

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160 views • 1 slides

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