Four UV spectrophotometric methodsfor estimation of paliperidone in bulk and their pharmaceutical dosage form
A simple, precise and economical methods of UV Spectrophotometry for the estimation of Paliperidone (PPD) in bulk and its formulation are pro- posed. PPD was estimated at 238.2nm, 236.8nm, 232nm, 232nm in etha- nol, ethanol and distilled water, diethyl ether, diethyl ether and distilled water, respectively. The precision expressed as relative standard deviation, which was within 2.0 % for the above four methods. These shows linearity over the concentration range of 0.2-1u00b5g/ml, 5-25u00b5g/ml, 2-10u00b5g/ ml, 10-100u00b5g/ml with regression equation 0.018x 0.004 (r 2 = 0.999), 0.179x 0.017 (r 2 = 0.999), 0.180 0.042 (r 2 = 0.998), 0.100x - 0.077 (r 2 = 0.999). The proposed methods can be successfully applied for the determination of PPD in dosage forms.
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