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Developmental Pharmacokinetics of Diclofenac for Acute Pain

Developmental Pharmacokinetics of Diclofenac for Acute Pain. Standing JF , Howard RF, Johnston A, Savage I, Wong ICK. Diclofenac. NSAID pKa ~ 4 Oral F (unchanged) = 60% Protein binding > 99.7% (Davies 1997) Linear PK between 50 and 150mg (Lau 1989)

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Developmental Pharmacokinetics of Diclofenac for Acute Pain