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Amyloid cascade hypothesis – the role of GSK3

Amyloid cascade hypothesis – the role of GSK3. Environment. Genes. GSK3. AT8. 1. Hanger et al. Neurosci.Lett. 1992;147:58-62. 2. Lovestone et al Curr Biol 1994;4(12):1077-86. 3. Lovestone et al Biol.Psychiatry 1999;45(8):995-1003. GSK-3 inhibitor.

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Amyloid cascade hypothesis – the role of GSK3

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GSK3 Signaling Pathway

Glycogen synthase kinase 3s are serine/threonine kinases which were originally found as key regulatory enzymes in glucose metabolism. Mammals express two GSK3 isoforms, one is GSK3α (51kDa) and the other is GSK3β (47kDa). They are encoded by different genes, which are about 85% homologous to each other, with 95% identity in the kinase domains.

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