'Heavy chain' diaporamas de présentation

Legends

Legends. For ETD data In the spectra v = precursor ions, charge-reduced ones too; * = charge-reduced ion from a coeluting precursor ion with different, usually (2+), charge; m = neutral sugar losses In the sequences residue in bold = corresponding z . or z+1 ion detected;

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??? ?????

??? ?????. Ab ????. 1890 ?? Behring ?????? Koch ????????????????? ????? ????????? ???????? 60% ????? 26% ? ? 1901 ?????????. ???????????? 1939Tiselius and Kabat ?. Immune sera. Normal sera. ??? antibody, Ab ? :

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Office Hours Color slides

Office Hours Color slides. Questions From Class. Is IgM only pentameric?

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Somatic recombination at the Ig heavy chain locus

*. *. D ? J H rearrangement. V ? DJ H rearrangement. Primary RNA transcript. Splicing and polyA ? mRNA. Nascent polypeptide. Mature ? heavy chain protein. Somatic recombination at the Ig heavy chain locus. Germline DNA. *. Variable Region gene Variable Region exon.

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Immunoglobulin Superfamily of Genes and Diversity of Antigen Recognition

Immunoglobulin Superfamily of Genes and Diversity of Antigen Recognition. Outline. Immunoglobulin Superfamily Antigen Recognition Members: Antibodies T-Cell Receptor Immense Diversity: The Problem: Package all that Information The Solution: Somatic Recombination

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Camel Nanotechnologies and its Medical Applications

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Catalysis: Concepts and Green Applications

Catalysis: Concepts and Green Applications. Lecture slides for Chapter 5 : Biocatalysis. Most of the graphics here were drawn using PowerPoint and Chemdraw (version Ultra 9.0). Feel free to modify and/or add your own pyrotechnics. Please send any feedback to feedback@catalysisbook.org.

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Immunoglobulin

IMMUNOLOGY. Immunoglobulin. immunoglobulin. Introduction the basic structure of immunoglobulins Fuction of immunoglobulins the structures and properties of immunoglobulin classes Monoclonal antibody. immunoglobulin. Introduction. Immunoglobulins (Ig)

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Microbial Biotechnology

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Basic Science Review A Tale of Three Proteins

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Organization and Expression of Immunoglobulin Genes

Organization and Expression of Immunoglobulin Genes. Reading. Chapter 5 Kuby et al Immunology 6 th Edition. OBJECTIVES. Define the following terms: allelic exclusion, isotype switching, affinity maturation , antibody repertoire, alternative RNA splicing, recombination signal sequence

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Muscle is classified into three types: skeletal, cardiac, and smooth muscle

Muscle is classified into three types: skeletal, cardiac, and smooth muscle. Muscle cells possess contractile filaments containing actin and myosin. Structure of Skeletal Muscle 1. Types of skeletal muscle cells include red

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Richard Ekanem Biology 506 HMG November 28, 2011

Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy. Author(s): Chang-Hao et al. Richard Ekanem Biology 506 HMG November 28, 2011. OVERVIEW. Introduction to DMD Objective(s) of the research

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Immunoglobulin Gene Rearrangement

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QUICK REVIEW

QUICK REVIEW. IMMUNOGLOBULINS. 1. A child stung by a bee experiences respiratory distress within minutes and lapses into unconsciousness. This reaction is probably mediated by A. IgE antibody. B. IgG antibody. C. sensitized T cells. D. complement. E. IgM antibody.

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Ex. 28: HIV ELISA, AIDS Diagnostic Tool

Ex. 28: HIV ELISA, AIDS Diagnostic Tool. Human Immuno-deficiency Virus (HIV). First diagnosed in 1981 Over 20 million deaths worldwide, over a half million in the United States Over 40 million currently infected, over a million in the United States

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UNC-54

UNC-54. Caenorhabditis elegans genome Chris Weaver | Bioinformatics | Spring 2008. Introduction. Uncoordinated protein 54 Also known as: myo-4 (Myosin-4) UNC-54 is required for locomotion and egg-laying Gene: F11C3.3 Transcripts: F11C3.3.1, F11C3.3.2, F11C3.3.3 Wormbase ID: WBGene00006789.

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Splicing

Splicing. Spliceosome-mediated splicing. Alternative Splicing. Regulated Splicing *splicing enhancers *splicing silencers. Alternative Splicing: Mouse immunoglobulin heavy chain. Alternative Splicing: Sex determination. Alternative Splicing: Drosophila sex determination.

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Insulin

A Novel Method to Measure Glucose Uptake and Myosin Heavy Chain Isoform Expression of Single Fibers From Rat Skeletal Muscle. Mackrell JG, Cartee GD. Diabetes . 2012;61(5):995-1003. Insulin. Glucose uptake. Insulin. I IIA IIB IIX. Glucose uptake. Myosin heavy chain. Myosin

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