'Hiv integrase' diaporamas de présentation

446 views • 32 slides

Model for HIV membrane fusion and its inhibition

Fuzeon (enfuvirtide; T-20) - a peptide inhibitor of fusion. Model for HIV membrane fusion and its inhibition. Target. fusion peptide. Transmembrane region of gp41. Chan et al (1997) Cell 89:263. www.hivandhepatitis.com/hiv_and_aids/fuzeon1.html.

515 views • 26 slides

Site directed mutagenesis Y143C Q148H N155H G140S+Q148H

# 2970 Effects of HIV integrase polymorphisms on raltegravir -resistance susceptibility. H Suzuki 1 , M Maejima 2 , H Ode 2 , J Hattori 2 , M Nishizawa 1 , S Ibe 2 , Y Iwantani 2,3 , Y Yokomaku 2 , W Sugiura 1,2,3

118 views • 2 slides

HIV Integrase

HIV integrase consists of three domains, the structures of which have been individually determined by X-ray crystallography or NMR spectroscopy. The core domain, spanning residues 50-212, is responsible for the catalytic activity of the enzyme. The crystal structure of a dimer of this domain shows similarity to other proteins that carry out polynucleotidyl transfer, including MuA transposase and RNase H.

18 views • 1 slides