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Lessons on Protein Structure from Lattice Model HC Lee 李弘謙 Nanjing University Nanjing, China

Lessons on Protein Structure from Lattice Model HC Lee 李弘謙 Nanjing University Nanjing, China 2002 May 22 – 25. What is a protein?. Large molecule: chain of amino acids Several tens to thousands residues Folds to specific shape Biological machines. DNA &amp; Gene.

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HP model

HP model. HP model for protein folding K. Dill, Theory for the folding and stability of globular proteins. Biochemistry, 24:1501-1509, 1985. red - Hydrophobic ; blue - Polar (hydrophylic) molecules. Reasons why HP model can explain some key features of protein folding. HP model “game”.

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Journal club 3/20/2006 by Peng-Liang Wang

Shaping up the protein folding funnel by local interaction: Lesson from a structure prediction study George Chikenji*, Yoshimi Fujitsuka , and Shoji Takada* PNAS | February 28, 2006 | vol. 103 | no. 9 | 3141-3146. Journal club 3/20/2006 by Peng-Liang Wang. Introduction.

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293 views • 18 slides

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