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Cell Biology - Models The NF- k B/I k B System

Cell Biology - Models The NF- k B/I k B System. Yurochko February 19-20, 2008. Lecture Goal & Outline. Goal: To introduce you to a model of signal transduction and specifically examine a signaling pathway. The pathway being the NF- k B/I k B regulatory pathway. Outline: NF- k B I k Bs

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949 views • 46 slides

Role of NF- ? B in the Regulation of Immunity and Apoptosis

Role of NF- ? B in the Regulation of Immunity and Apoptosis. Kavitha Bharatham. Abstract. Introduction Structural Description Role as regulator of Immune responses Role as regulator of apoptosis Regulation Mechanism As target for Therapy Conclusions. Introduction.

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356 views • 30 slides

Figure 3

Ub. Ub. Ub. Ub. Ub. TNF a. receptor. cytoplasm. adaptor proteins. IKK kinase complex. a. b. IKK complex. NEMO. I k B. NF- k B. 26S proteasome. Phosphorylation of I k B. Ubiquitination and degradation of I k B. NF- k B. ubiquitin. Ub. nucleus. Gene expression.

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107 views • 1 slides

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Cell Biology - Models The NF- k B/I k B System

Role of NF- ? B in the Regulation of Immunity and Apoptosis

Figure 3