Induced pairwise alignment - PowerPoint PPT Presentation

CS 5263 Bioinformatics

CS 5263 Bioinformatics. Lecture 8: Multiple Sequence Alignment. Roadmap. Homework? Review of last lecture Multiple sequence alignment. Homework. #1: dsDNA =&gt; mRNA =&gt; protein. Coding strand. Template strand. The genetic code. mRNA. Template strand. mRNA. protein. Problem #2.

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Scoring a multiple alignment

Scoring a multiple alignment. A. A. A. A. C. A. C. A. C. A. C. C. A. C. A. Sum of pairs. Star. Tree. A. AAA AAA AAA AA C A CC. A. C. A. A. A. A. A. A. A. C. 10 α. + (6 α - 4 β ). + (4 α - 6 β ). A. A. A. C. Sum of Pairs. = 20 α - 10 β.

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Multiple Sequence Alignment

Multiple Sequence Alignment. Mult-Seq-Align allows to detect similarities which cannot be detected with Pairwise-Seq-Align methods. Detection of family characteristics. Three questions: 1. Scoring Computation of Mult-Seq-Align. Family representation. Multiple Sequence Alignment.

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