ENZYME CASCADES: BLOOD CLOTTING. Medical Biochemistry, Lecture 27. Lecture 27, Outline. The extrinsic and intrinsic clotting pathwaysBy MartaAdara
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Blood Clotting. Serum + blood clot gel Fibrin traps formed elements Coagulation Thrombosis Embolus. Blood Clotting. Chemicals involved: Ca 2+ Inactive enzymes Molecules from platelets Molecules from damaged tissues Requires Vitamin K and Ca 2+ Uncontrolled bleeding. Blood Clotting.
Blood Clotting. Lecture 8. Dr. Gihan Gawish. Coagulation. Coagulation is a complex process by which blood forms clots. Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium (lining of the vessel).
Blood Clotting. April 21, 2005 . Blood clotting system. Precise control of the blood-clotting system is essential for maintenance of the circulation in all higher animals. Deficient function of this system can lead to fatal bleeding following even a minor injury.
Blood Clotting. Robin Gray. Blood Clotting AKA Coagulation. TQ. Cardiovascular System Not necessarily a “balancing” effect It prevents massive blood loss Hemostatis – the cessation of blood loss from a damaged vessel. TQ. Organs and Cells Involved. Veins and arteries Vessel sides
Blood clotting. Dubravka Šipuš, 2nd year 2013/2014 Mentor: A. Žmegač Horvat. Hemostasis. Hemostasis – prevention of blood loss Mechanisms: Vascular constriction Formation of a platelet plug Formation of a blood clot Growth of fibrous tissue. Blood coagulation. Fast process
Blood Clotting. The Coagulation Process. What is Blood?. Blood is a fluid that carries nutrients, gases, and wastes through the body. The blood consists of these components: Red blood cells, white blood cells, platelets, and plasma.
Blood Clotting Pathway. Prothrombin Thrombin. Vitamin K. Adds γ COO- to glutamate of prothrombin. Also VII IX X. Coumadin Inhibits vit K action. Thrombin (hydrolysis at arginine-glycine). 3. A α B β γ. 2. Fibrinogen. Fibrino peptide 2A+2B.
Bleeding and Clotting. Hemostasis. Normal Hemostasis - Arrest of Bleeding Platelets Clotting/Coagulation Factors Blood Vessels /Vasculature Control of Hemostatic Mechanisms Properties of Normal Vascular Endothelium Prevent Clotting Smooth Texture of Endothelial Lining
The are two interrelated clotting pathways:Intrinsic system and the extrinsic system require the successive activation of specific plasma clotting factors.Defects in these factors can be detected by means of two clotting-time tests.. Objectives. Describe the intrinsic and extrinsic clotting sy