Known inhibitors - PowerPoint PPT Presentation

Brian Grieb October 27, 2004 Future Directions in Chemistry

M. tuberculosis Drug Development. New Inhibitor of Cell Wall Biosynthesis. Brian Grieb October 27, 2004 Future Directions in Chemistry. Why Drug Development?. What is TB? infection of the lungs by Mycobacterium tuberculosis Statistics in 2002, over 2 million died

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Interpreting expression data with metabolic flux models

Predict Lipid Source Short chain Long chain Branched/Odd-Chain Fas Cholesterol Use in vivo TB expression to predict phagolysome environment Gary Schoolnick - RT-PCR from resected human lung samples. Effect of Drug. 3. 2. Increased. 1.

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