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Linkage Analyisis II Phylogenic trees

Linkage Analyisis II Phylogenic trees

Linkage Analyisis II Phylogenic trees. Goals. Given marker genes, we want to know the position of genes linked to a given phenotype. We use genes with multiple alleles (for the marker). For example a gene in which a SNP occurred and is present in some of the population.

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836 views • 72 slides
Linkage Analyisis II Phylogenic trees

Linkage Analyisis II Phylogenic trees

Linkage Analyisis II Phylogenic trees. Goals. Given marker genes, we want to know the position of genes linked to a given phenotype. We use genes with multiple alleles (for the marker). For example a gene in which a SNP occurred and is present in some of the population.

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725 views • 72 slides
LINKAGE ANALYSIS

LINKAGE ANALYSIS

LINKAGE ANALYSIS. Recombination Fraction. During synapsis , crossing-over may occur between any two non-sister chromatids If there are allelic differences at the site of crossing over, the genetic result is recombination Genes on the same chromosome are connected physically (syntenic)

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791 views • 46 slides
More About LOD Scores

More About LOD Scores

More About LOD Scores. 2012. a) Relatedness. Backcross, F 2 , Recombinant inbred lines Humans: Need to be able to compare maps between groups Need suitable families for analysis - large, multigenerational. The Centre d'Etude du Polymorphism Humain (CEPH). Form P. Form Q. 1%. 99%. 15%.

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422 views • 34 slides
Appropriate populations or families

Appropriate populations or families

Appropriate populations or families. a) The relatedness of the individuals to be analyzed b) How much variability (polymorphism) there is in the analyzed group of individuals c) Whether (and how) the group can be maintained for use over time and between research groups d) Size of group.

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431 views • 33 slides

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