'Low frequency polymorphisms' diaporamas de présentation

Rates and Fitness Effects of Mutations

Rates and Fitness Effects of Mutations. Adam Eyre-Walker (University of Sussex). -ve. +ve. 0. Types of Mutation. Deleterious Neutral Advantageous. K = 10% 10% sites mutated. K = 2% 80% mutations deleterious. DNA Sequence Data. Assume all mutations are neutral or deleterious.

589 views • 47 slides

The Distribution of Fitness Effects of Mutations in Humans and Flies

The Distribution of Fitness Effects of Mutations in Humans and Flies. Adam Eyre-Walker (University of Sussex). -ve. +ve. 0. Types of Mutation. Deleterious Neutral Advantageous. Deleterious Mutations. Mutation accumulation and Mutagenesis expts. d n /d s in primates. <30%. <10%.

471 views • 30 slides

Perspectives from Human Studies and Low Density Chip

385 views • 24 slides