'Malonyl coa' diaporamas de présentation

Part two

TUMS. Vitamins and Coenzymes. Part two. Dr. Azin Nowrouzi, PhD Tehran University of Medical Sciences. 9. FOLIC ACID (folacin). Folacin includes several derivatives of folic acid (monopteroylglutamic acid).

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Digestion and absorption of lipids and Fatty acid synthesis ?????????????

Digestion and absorption of lipids and Fatty acid synthesis ?????????????. Deqiao Sheng PhD Biochemistry Department. Most lipids are ingested in the form of triacylglycerols. Dietary lipids are digested by pancreatic lipases .

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* Lipid Biosynthesis

* Lipid Biosynthesis - These are endergonic and reductive reactions, use ATP as source of energy and reduced electron carrier usually NADPH as reductant. * Fatty acid synthesis: - F.A synthesis is not the reversal of the degradative pathway, using different sets of enzymes.

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Chapters 8 & 18: Metabolism and Movement of Lipids

Chapters 8 & 18: Metabolism and Movement of Lipids. What types of fats are needed for cell function? Where are each of these types of fats manufactured? How do phospholipids in the outer leaflet of the plasma membrane get there? How do lipids move from place to place in the cell?

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Fatty acid breakdown

Fatty acid breakdown. The oxidation of fatty acids proceeds in three stages. b -oxidation. b -oxidation is catalyzed by four enzymes Acyl-CoA dehydrogenase Enoyl-CoA hydratase b -hydroxyacyl-CoA dehydrogenase Acyl-CoA acetyltransferase (thiolase). First step. Isozymes of first enzyme

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D- Fatty Acid Synthesis

D- Fatty Acid Synthesis. The input to fatty acid synthesis is acetyl-CoA , which is carboxylated to malonyl-CoA. ATP-dependent carboxylation provides energy input. The CO 2 is lost later during condensation with the growing fatty acid.

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Vitamins B 6 and B 12

Vitamins B 6 and B 12. General biochemistry Functions Deficiency diseases. Classification of Vitamins. Water-Soluble Vitamins. B vitamins Thiamin (B 1 ), riboflavin (B 2 ), niacin (B 3 ), pantothenic acid (B 5 ), pyridoxine (B 6 ), biotin (B 7 ), cobalamin (B 12 ), folate

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Biosynthesis

Biosynthesis. Also known as anabolism Construction of complex molecules from simple precursors Energy derived from catabolism used in biosynthesis. Sulfur assimilation Sulfur is required for the formation of cysteine, methionine and many cofactors

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FATTY ACID SYNTHESIS

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b R

Fat mobilization in adipocytes. b R. Note: insulin inhibits TAG mobilization. PKA. PKA. P. Hormone-sensitive lipase. Hormone-sensitive lipase. glycerol. MAG. DAG. TAG. FFA. FFA. FFA. See Fig 16.7 Horton. Fatty acid oxidation. Activation Transport into mitochondria

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BIOC/DENT/PHCY 230 LECTURE 8

BIOC/DENT/PHCY 230 LECTURE 8. Transport and delivery of dietary lipids. dietary triacylglycerol (TAG) and cholesterol are delivered to target tissues by lipoproteins the four main lipoproteins are: chylomicrons VLDL LDL HDL.

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Bioc 460 Spring 2008 - Lecture 36 (Miesfeld)

Lipid Metabolism 2: Acetyl-CoA carboxylase, fatty acid synthase reaction, and regulation of fatty acid synthesis. C247. Bioc 460 Spring 2008 - Lecture 36 (Miesfeld). The fatty acid synthase enzyme in eukaryotes is dimer of two very large polypeptide chains, each encoding seven functional units.

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Refer to chapters 12 & 22, Stryer, 5e

A switch from catabolic to anabolic metabolism: the synthesis of fat in the body. Explain why the process of fat synthesis leads to the formation of fatty acids with even numbers of carbon atoms Explain why animals cannot carry out net glucose synthesis from fatty acids

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Fatty Acid Oxidation Defects

Fatty Acid Oxidation Defects.

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Nuts and Bolts The terpene lecture is on the web The phenylpropanoid lecture is on the web Final exam Saturday, May 18 -

Nuts and Bolts The terpene lecture is on the web The phenylpropanoid lecture is on the web Final exam Saturday, May 18 - 105 Tureaud 10 am to noon. Fig. 24.46. Fig. 24.46. Products of the shikimic acid pathway are the building blocks of plant phenolics. Fig. 24.52. Fig. 24.66.

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NATURAL PRODUCT CHEMISTRY

NATURAL PRODUCT CHEMISTRY. TRI JOKO RAHARJO. Scopes. Introduction Primary metabolism Biosynthesis pyruvate Biosynthesis shikimate Lignin and lignan Extension of phenil propanoate Polyketide and Flavonoid Terpenoid Alkaloid Isolation and Identification. Introduction.

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Lecture 12

Lecture 12. Fatty Acyl Synthase and Pentose Phosphate Pathway. Malonyl-CoA. Activated acetyl-CoA Tagged and primed for lipogenesis But also a key regulator of fatty acid oxidation ACC is not only present in lipogenic tissues

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Lecture 11

Lecture 11. Lipogenesis. Overview. glucose. Fat. ESTERIFICATION. GLUT-4. No GS. X. fatty acids. glucose. G6P. Consumes reductant and ATP. GLYCOLYSIS. PPP. LIPOGENESIS. Produces reductant. pyruvate. acetyl-CoA. pyruvate. acetyl-CoA. PDH.

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GAP

?. CO 2. (?). ??????. ??????. ?????. ?????. ??. ??????. ( ?? ). RuBP. Glct. Ru5P. G6P. 6PG. Glucose. ?. (??????). (??????). (?????). (?????). (??). CO 2. ( ? ?? ??? ). (?????). (?????). ??. (??). ??????. R5P. X5P. F6P. GLX. (??????). ( ??? ). ?????. ?????.

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BSX

Supplementary Figure 6. Ghrelin. GHS-R. VTA. KOR. KOR. NAc. dopamine. ?. Food intake. HYPOTHALAMUS. Ghrelin. FOXO1. pCREB. GHS-R. pACC. BSX. AgRP. pAMPK. NPY. GHS-R. Ghrelin. ACC. Acetiyl-CoA. Malonyl-CoA. MCD. FAS. Palmitoyl. CPT-1. UCP2. ?-Oxidation. mitochondria.

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