'Map kinase' diaporamas de présentation

Lymphocyte Signal Transduction

Lymphocyte Signal Transduction. Arnold B. Rabson CHINJ. Lymphocyte Signal Transduction. Basic Common Principles: B and T cells T Cell Activation Signaling The Immunological Synapse Membrane events Signal transduction molecules Transcriptional Regulation Cytoskeletal Reorganization

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Signaling by Tyrosine Phosphorylation in the Nervous System

Signaling by Tyrosine Phosphorylation in the Nervous System. Introduction. Protein phosphorylation represents the most common form of posttranslational modification in nature Protein function altered by addition of a negatively charged phosphate group to a Ser, Thr , or Tyr residue:

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Hanahan and Weinberg (2000) Cell 100: 57.

Signal Transduction Cross-Talk Plays a major Role in Biology. Hanahan and Weinberg (2000) Cell 100: 57. Sixteen (or more) Different Classes of Receptor Signaling Pathways. from Pollard & Earnshaw '02. Overview of MAP kinase pathways. Growth factors and caclium. Cytokines Cellular stress.

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Hanahan and Weinberg (2000) Cell 100: 57.

Signal Transduction Cross-Talk Plays a major Role in Biology. Hanahan and Weinberg (2000) Cell 100: 57. Sixteen (or more) Different Classes of Receptor Signaling Pathways. from Pollard & Earnshaw '02. Overview of MAP kinase pathways. Growth factors and caclium. Cytokines Cellular stress.

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How does receptor engagement lead to lymphocyte activation?

How does receptor engagement lead to lymphocyte activation?. Y. ?. Basic signal transduction. -signals are transmitted through changes in specific activity or location of proteins

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SIGNAL TRANSDUCTION 2) From the cell membrane to the nucleus Part B

SIGNAL TRANSDUCTION 2) From the cell membrane to the nucleus Part B 1-TM RECEPTORS AND ASSOCIATED SIGNALLING CASCADES Erhard Hofer Department of Vascular Biology and Thrombosis Research Vienna Competence Center, Lazarettgasse 19, A-1090 Wien. Signal transduction: receptor gene. 1.

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Lymphocyte Activation Receptor signal transduction David Straus dbstraus@vcu

Lymphocyte Activation Receptor signal transduction David Straus dbstraus@vcu.edu Reading: Janeway text; 6-1 to 6-17. Specificity of T lymphocyte activation relies upon TCR recognition of MHC-peptide: a relatively low affinity interaction compared to immunoglobulin. TCR. MHC- peptide.

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Map Kinase (Map = mitogen-activated protein kinases) what is a kinase?

Map Kinase (Map = mitogen-activated protein kinases) what is a kinase?. Text pages: 406-411; 596-597 Go through web sites on map kinase- see course web page. Insulin and many growth factors or mitogens act through Map kinase. MAPK overstimulation may cause:.

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Alpha5 integrin dependent 3D attachment, appearance, and migration

Alpha5 integrin dependent 3D attachment, appearance, and migration. (Not 2D). (pliable). (cell-derived). Some early studies in 3-Dimensional Substrates: Bissell lab. HMT-3522 Breast Epithelial cells S-1: nonmalignant T4-2: tumorigenic Grown on plastic: 2 cell lines appear similar

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Lymphocyte Activation Receptor signal transduction David Straus dbstraus@vcu

Lymphocyte Activation Receptor signal transduction David Straus dbstraus@vcu.edu Reading: Janeway text; 6-1 to 6-17. How does receptor engagement lead to lymphocyte activation?. Y. ?. Basic signal transduction.

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Dr. R.A.SIDDIQUE M.V.Sc., PhD Scholar National Dairy Research Institute, Karnal, Haryana, 132001

THE ASK1-MAP KINASE CASCADES IN MAMMALIAN STRESS RESPONSE. Dr. R.A.SIDDIQUE M.V.Sc., PhD Scholar National Dairy Research Institute, Karnal, Haryana, 132001 INDIA E-mail: riazndri@gmail.com. STRESS:

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IBS 501 Introduction to Cell Biology Lecture 3 Effectors of RTKs and GPCR signaling;

IBS 501 Introduction to Cell Biology Lecture 3 Effectors of RTKs and GPCR signaling; TGF- ? signaling and JAK/STATs Instructor: Karl Saxe Readings: Lodish et al., pages 878-906; 1004-1007; Alberts et al., pages 499-509. OUTLINE 1. Return to Second Messengers a. cAMP and PKA

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Cell Signaling & Signal Transduction

Cell Signaling & Signal Transduction. Steroid hormones (also thyroid hormone) enter cells to regulate gene expression. Signal molecules too big or polar to enter a target cell transmit information by signal transduction ,. Signal Transduction Themes: intracellular 2nd messengers

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Intercellular communication Intracellular signals Gene regulation

Signal transduction: receptor gene. 1. Intercellular communication Intracellular signals Gene regulation. 2. Ligand. 3. Surface receptor. cell. Intracellular receptor. nucleus. Gene. 1- TF activation via signalling cascades 2- TF activation at the receptor

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Liu et al. (1995) The Journal of Biological Chemistry

Role of Mitogen-activated Protein Kinase Phosphatase During the Cellular Response to Gentoxic Stress :Inhibition of c-Jun N-Terminal Kinase Activity and AP-1 Dependent Gene Activation. Liu et al. (1995) The Journal of Biological Chemistry. UV Light. Introduction.

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MICR 304 Immunology & Serology

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Signal Transduction Pathways

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Cell Signaling

Cell Signaling. Lecture 10. Ras /MAP Kinase Pathway. Receptor tyrosine kinase Cytokine receptors G Protein. Activate this pathway. Ras. Activation of. Ligand. Binding to. Receptor. Formation of. Regulation of. Transcription factor. MAP Kinase. Kinase cascade. Activation of.

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CDV Raamsdonk et al. Nature 000 , 1- 4 (2008) doi:10.1038/nature0758 6

GNAQ Q209L induces MAP kinase activation. CDV Raamsdonk et al. Nature 000 , 1- 4 (2008) doi:10.1038/nature0758 6.

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MAP Kinase Signaling Pathways

MAP Kinase Signaling Pathways

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