'Mcf 7' diaporamas de présentation

Meccanismo di azione e superamento della resistenza ormonale

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Elucidation of Mechanisms of Action of Novel Antitumour Agents

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Functional Genomic Analysis of Autophagic Cell Death using RNA interference

CATGGCGATATTGT CATGGCGCCAATAT CATGGCGCGCATTT CATGGCGTGGGGAT CATGGCTAATAAAT CATGGCTCAAGGAG CATGGCTGGACTCC CATGGCTGTGGCCA CATGGCTTTCGTGT CATGGCTTTTTGGC CATGGGAACCGACA CATGGGACCGCCCC CATGGGACCGCTCA CATGGGATCACAAT CATGGGCAACGATC CATGGGCAGCAAGC CATGGGCAGCAATT.

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Functional Genomic Analysis of Autophagic Cell Death using RNA interference

CATGGCGATATTGT CATGGCGCCAATAT CATGGCGCGCATTT CATGGCGTGGGGAT CATGGCTAATAAAT CATGGCTCAAGGAG CATGGCTGGACTCC CATGGCTGTGGCCA CATGGCTTTCGTGT CATGGCTTTTTGGC CATGGGAACCGACA CATGGGACCGCCCC CATGGGACCGCTCA CATGGGATCACAAT CATGGGCAACGATC CATGGGCAGCAAGC CATGGGCAGCAATT.

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APAG-1 DERIVATIVES AS ANTITUMOUR AGENTS

APAG-1 DERIVATIVES AS ANTITUMOUR AGENTS.

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Journal Report

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NCI Mean GI 50 graph for NSC 721648, GW 610 (ii)

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Caspase-8

5-aza-dc - + - + - + - + - + -. CASP8. b- actin. 14. 12. 10. 5-aza-dc - - + + - -. M UM M UM M UM. 8. CASP8. Bisulfite sequence CASP8 promoter. MSP.

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MRC-5

A. BE(2)-C. MCF-7. Calu-6. B. C. BE(2)-C. MCF-7. MRC-5.

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LITR

A. B. ? E1. ? E3. AdGFP. LITR. GFP. RITR. C. ? E1. ? E3. AdER ?. D. MCF-7 2,000 particles/cell. LITR. GFP. ER ?. RITR. AdER ? + E2. AdGFP + E2. AdER ? No Ligand AdGFP No Ligand. E.

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A B C

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GAPDH

A. MDA-MB231. MDA-MB231. MDA-MB231. MCF 7. MCF 7. MCF 7. MsrA. GAPDH. B. MsrA. Sp1. b -actin. b -actin.

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Fig. 1 ( Supplementary data)

Fig. 1 ( Supplementary data). c. 35. PR. ER. 30. 25. 20. RT-qPCR Ct values. 15. 10. 5. 0. HBE. MCF-7. T47-D. a. PR. ER. NC. b. CK18.

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U251 MCF-7 A549

U251 MCF-7 A549. - + - - + - - + - scrambled ODN - - + - - + - - + As-miR-221/222. U6. miRNA-221. miRNA-222.

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Sansone et al, Supplementary Figure 2

HYPO-7. A. 1 MONTH 6 MONTHS 1 YEAR. B. c. 1 MONTH 6 MONTHS 1 YEAR. HYPO-7. MCF-7 + - + - + - HYPO-7 - + - + - +. DFX 600 m M - +. CA-IX.

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A B

A B. Supplementary Figure 3. Transcriptional Co-activator and Co-Repressors Expression in MLET5 Cells.

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MCF-7

Origin. Origin. MCF-10A. MCF-7. 1. 1. P. P. 2. 2. 5. 5. 3. 3. 4. 4. 6. 6. 7. Solvent System 1. 8. Solvent System 2.

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Fig. 2

Fig. 2. A. B. 20. 30. BT-474. cells/well. MCF-7. 25. 15. ?. ?. 20. 4. ?. 10. 10. ?. 15. 10. 5. siRNA1. C. OF. siGFP. siRNA2. siRNA3. 5. 0. 0. G0/G1. G0/G1. 80. S. S. G2/M. G2/M. BT-474. MCF-7. 60. 60. 40. 40. %. %. 20. 20. 0. siRNA1. siRNA1.

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