'Mhc molecules' diaporamas de présentation

Chapter 8 The Major Histocomptibility Complex (MHC) and Ag Presentation Chapter 9

Chapter 8 The Major Histocomptibility Complex (MHC) and Ag Presentation Chapter 9 T-cell Receptor Chapter 10 T-cell Maturation, Activation, and Differentiation. Chapter 8 The Major Histocomptibility Complex (MHC) and Ag Presentation. Nov 21, 2006. ????????? MHC ???????

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Chapter 11 Antigen Presenting Cells and Antigen Presenting

Chapter 11 Antigen Presenting Cells and Antigen Presenting. B. B. B. B. B. B. B. B. B. Y. Y. Y. Y. Y. Y. Y. Y. Y. Y. T. T. Y. Y. T cells do not recognise native antigens. Y. Y. Y. Y. Y. Y. Cross-linking of surface membrane Ig.

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The MHC complex: genetics, function and disease association

The MHC complex: genetics, function and disease association. Lecturer: Adelheid Cerwenka, PhD, D080, Innate Immunity Sources: Janeway: Immunobiology, 5th edition Kuby: Immunology, 4th edition Klein/Horejsi:Immunology 2nd edition. Only complementary surfaces fit together. MHC-structure.

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Lecture 11 Immunology and disease: parasite antigenic diversity

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Chapter21 Transplantation Immunology

Chapter21 Transplantation Immunology. History of transplantation ?? ?? ???? 1900 Landsteiner*(1930) ?????????????? 1912 Carrell* ?????

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INSTITUTE FOR IMMUNOBIOLOGY

INSTITUTE FOR IMMUNOBIOLOGY. Major Histocompatibility Complex MHC Department of Immunology Fudan University Bo GAO, Ph.D 021-54237154 gaobo@fudan.edu.cn. Major Histocompatibilty Complex, MHC. 1. Discovery of MHC MHC Genes Binding of Peptides to MHC Molecules MHC polymorphism

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Chapter 6 Immunocytes

Chapter 6 Immunocytes. Xu Qin. Immune cells. Specific immune response cells ( T cell ? B cell and APC ) ? Non-specific immune response cells ( phagocyte ? NK cell, NKT cell ? Neutrophils ? Macrophages and Mast cells ). Origin and Differentiation of Immunocytes.

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Lecture outline

Lecture outline. Signals for T cell activation Costimulation and the B7:CD28 family Responses of T cells Cytokines . The life history of T lymphocytes. c. Abbas, Lichtman and Pillai . Cellular and Molecular Immunology, 7 th edition, 2011 . Elsevier.

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The Major Histocompatibility Complex (MHC)

The Major Histocompatibility Complex (MHC). In all vertebrates there is a genetic region that has a major influence on graft survival This region is referred to as the Major Histocompatibility Complex (MHC)

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Innate Immunity (part II) and Antigen Recognition by Adaptive Immunity

Innate Immunity (part II) and Antigen Recognition by Adaptive Immunity. Innate Immunity against viruses. Anti-viral immunity has 2 roles Blocking infection (antibodies, complement, etc.) Blocking viral replication (interferon, killing infected cells, anti-nucleic acid mechanisms)

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October 11, 2005 Walter A. Orenstein, M.D. Professor of Medicine and Pediatrics Director, Emory Vaccine Policy and Devel

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Reminders

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Antigen Processing & Presentation

Antigen Processing & Presentation .

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The Immune System

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Lecture 2 ANTIGENS AND THEIR PROCESSING 2013/2014

Lecture 2 ANTIGENS AND THEIR PROCESSING 2013/2014. ANTIGENS. The structure of antigens Antigen processing and presentation Peptide-MHC molecule: structure and assembly Antigen recognition by B and T cells Superantigens Stress proteins (heat shock proteins).

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FUNCTION OF MHC MOLECULES

FUNCTION OF MHC MOLECULES. THE STRUCTURE OF MHC GENE PRODUCTS. ?2. ?1. ?1. ?1. ?3. ?2. ?2. ?2m. ?1 ?2 ?3. ?1 ?2. ?1 ?2. ?3 and ?2m Ig supergene family ?2 and ?2. ? 2. ? 1. ? 2 m. ? 3. THREE DIMENSIONAL STRUCTURE OF THE MHC CLASS I MOLECULE. PEPTIDE.

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Autoimmunity

Autoimmunity. Autoimmunity. Loss of self tolerace leading to immune response to self tissues May be organ-specific, localized or systemic Genetic background plays a role in extent & severity of diseases. Virtually all autoimmune responses are T-dep. Formation of new or altered epitopes

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??? ???? ?????? ??????

??? ???? ?????? ??????. Cell Mediated Immunity. Cell Mediated Immunity. * Host defenses against extracellular infection are mediated by: - Antibody - Complement - Macrophages * Intercellular infections are mediates by CMI

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MHC Molecules

MHC Molecules. Our immune system has the remarkable ability, and responsibility, of responding appropriately to a wide variety of potential pathogens in our environment.

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Ashref Kassim, gr.2

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