NCBI Molecular Biology Resources. Using Entrez. January 2008. WWW Access. Entrez & BLAST. Entrez: Database Integration. Word weight. PubMed abstracts. 3-D Structure. 3 -D Structure. Homologene. VAST. Gene. Neighbors Related Structures. Protein sequences. Nucleotide sequences.By ewa
NCBI Molecular Biology Resources. Using Entrez. January 2008. WWW Access. Entrez & BLAST. Entrez: Database Integration. Word weight. PubMed abstracts. 3-D Structure. 3 -D Structure. Homologene. VAST. Gene. Neighbors Related Structures. Protein sequences. Nucleotide sequences.By jacobsr
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MLH1 and HNPCC. March 29, 2005 Tammy Jernigan. http://www.macgn.org/cc_hnpcc1.html. Type I Site Specific Colorectal Cancer. Type 2 Colorectal Cancer Extracolonic Cancers: -Endometrial (80%) -Ovarian -Stomach, Urologic.
HNPCC and MLH1. Qi Peng Cancer Biology March 30 th , 2006. Hereditary Nonpolyposis Colon Cancer (HNPCC). An inherited cancer of digestive tract, especially increases risk of colon cancer. Increases women’s risk of getting, endometrial and ovarian cancer May also cause colon polyps. .
MLH1 / MSH2 Mutation Prevalence. N=1434 **Estimate calculated according to PREMM 12 model; Myriad’s N<50. PREMM12 model can be found at: http://www.dana-farber.org/pat/cancer/gastrointestinal/crc-calculator/default.asp www.myriadtests.com.
MLH1 and Hereditary Non-Polyposis Colorectal Cancer. An investigation of DNA mismatch repair By: Daniel Driskill March 22, 2007. HNPCC. Aka: Lynch Syndrome Susceptibility to: Endometrial, stomach, ovarian, and urinary tract, and colon carcinomas Very specific criteria for diagnosis
MLH1: Hereditary non-polyposis colon cancer (HNPCC). By: Alison Edge. Normal MLH1 Function. Makes a protein that plays an essential role in DNA mismatch repair system (MMR). Human Molecular Genetics, 2001, Vol. 10, No. 7 pg 736. Functions of MMR System. Post replication repair
PhIP-induced Mutation in Mlh1 -deficient Mice. Stacy Hill. Significance. 2-5% of all colorectal cancer cases in humans result from a genetic predisposition called hereditary nonpolyposis colorectal cancer (HNPCC). HNPCC is the most commonly inherited form of colorectal cancer.
MLH1 and Hereditary Non-polyposis Colon Cancer. Walter Ratchford 3/4/04. Outline. Explanation of MMR in DNA replication Description of MLH1 and its role in MMR The link between hereditary non-polyposis colon cancer and MLH1. DNA Mismatch Repair (MMR).
A GENETIC MODEL FOR PREDICTING THE CARRIER STATUS OF MSH2/MLH1 MUTATIONS: RESULTS OF AN ITALIAN MULTICENTER STUDY