'Mrna degradation' diaporamas de présentation

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Genes and Protein Synthesis

Genes and Protein Synthesis. Chapter 7. One Gene-One Polypeptide Hypothesis. DNA contains all of our hereditary information Genes are located in our DNA ~25,000 genes in our DNA (46 chromosomes) Each Gene codes for a specific polypeptide. Main Idea. Central Dogma Francis Crick (1956).

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Gene regulation

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Control of Gene Expression

Control of Gene Expression. Chapter 16. Control of Gene Expression. Controlling gene expression is often accomplished by controlling transcription initiation. Regulatory proteins bind to DNA to either block or stimulate transcription, depending on how they interact with RNA polymerase.

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Modified Central Dogma of Francis Crick (1958)

Gene Expression Prokaryotic Gene Transcription G & G Chapter 29 9/14/11 Thomas Ryan, Ph.D. Biochemistry and Molecular Genetics tryan@uab.edu. Modified Central Dogma of Francis Crick (1958). Prokaryotic Chromosome ( E. coli ). Large circular chromosome - 4.6 x 10 6 bp

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Regulating gene expression Goal is controlling Proteins How many? Where? How active?

Regulating gene expression Goal is controlling Proteins How many? Where? How active? 8 levels (two not shown are mRNA localization & prot degradation). mRNA PROCESSING Primary transcript is hnRNA Is capped, spliced and poly-adenylated before export to cytosol Many are also edited

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Chapter 19.

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Regulation of gene expression at the mRNA level: RNA interference and microRNAs

Regulation of gene expression at the mRNA level: RNA interference and microRNAs. Overview: The silencing effect of double-stranded RNA The mechanism: Dicer, RISC, Argonaute and siRNAs microRNAs: Nobel Prize in the next few years?. The breakthrough paper that started

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EE 193/Comp 150 Computing with biological parts

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Simulations of Stochastic Biological Phenomena

Simulations of Stochastic Biological Phenomena. Fernand Hayot, PhD Department of Neurology Mount Sinai School of Medicine fernand.hayot@mssm.edu. 1. Part 1 . Modeling Stochastic Systems: The Master Equation.

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Simulations of Stochastic Biological Phenomena

Simulations of Stochastic Biological Phenomena. Fernand Hayot, PhD Department of Neurology Mount Sinai School of Medicine fernand.hayot@mssm.edu. 1. Part 1 . Modeling Stochastic Systems: The Master Equation.

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RNAi

RNAi. What is RNAi?. RNA-based mechanisms of gene silencing. These siRNAs are bound by a protein-RNA complex called the RNA-induced silencing complex (RISC). Mello and Fire.

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Control of Eukaryotic Genes

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Gene Expression

Gene Expression. Cell Differentiation. Cell types are different because genes are expressed differently in them. Causes: Changes in chromatin structure Initiation of transcription RNA processing mRNA degradation Translation Protein processing and degradation. Operons.

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mRNA Degradation vs Translation

mRNA Degradation vs Translation. Proteome-wide alterations in Escherichia coli translation rates upon anaerobiosis. 2010. C ombined fractional diagonal chromatography

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miRNA

miRNA. Published online before print March 7, 2006, 10.1073/pnas.0601268103 PNAS | March 14, 2006 | vol. 103 | no. 11 | 3951-3952 Institution: Bolivia: PNAS Sponsored Commentary: MicroRNAs: New players in an old game Malavika Gupta, and Gary Brewer*

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