Nucleosome o - PowerPoint PPT Presentation
BIO 402/502 Advanced Cell & Developmental Biology I
BIO 402/502 Advanced Cell & Developmental Biology I. Section IV: Dr. Berezney. Lecture 1. The Cell Nucleus and its Genome. Organization of Eukaryotic Genome. Contrasting features of prokaryotic and eukaryotic genomes with respect to size, percent of coding region and number of genes.
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Nucleosome Positioning
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A Genomic Code for Nucleosome Positioning Authors: Segal E., Fondufe-Mittendorfe Y., Chen L., Thastrom A., Field Y., Moore I. K., Wang J.-P. Z., Widom J. Presented by Apostol Gramada DNA organization – Chromatin Taken from: http://sgi.bls.umkc.edu/waterborg/chromat/chroma09.html
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A Genomic Code for Nucleosome Positioning
A Genomic Code for Nucleosome Positioning . Authors: Segal E., Fondufe-Mittendorfe Y., Chen L., Thastrom A., Field Y., Moore I. K., Wang J.-P. Z., Widom J. Presented by Apostol Gramada. DNA organization – Chromatin . Taken from: http://sgi.bls.umkc.edu/waterborg/chromat/chroma09.html.
The genomic code for nucleosome positioning
DNA double helix. Nucleosomes. Chromosome. The genomic code for nucleosome positioning. Felsenfeld & Groudine, Nature (2003). DNA in nucleosomes is extremely sharply bent. Side view (Space filling representation). Top view (Ribbon representation). ~80 bp per superhelical turn.
A genomic code for nucleosome positioning
A genomic code for nucleosome positioning Hierarchical DNA folding in eukaryotic chromosomes DNA double helix Nucleosomes Felsenfeld & Groudine,, Nature 421: 448-453 (2003) Most eukaryotic DNA is sharply looped Luger et al., 1997 Random 220-mer pool (1 each of 5 x 10 12 individuals)