Orthologous sequences - PowerPoint PPT Presentation

Gibbs Sampling in Motif Finding

Gibbs Sampling in Motif Finding. Gibbs Sampling. Given : x 1 , …, x N , motif length K, background B, Find : Model M Locations a 1 ,…, a N in x 1 , …, x N Maximizing log-odds likelihood ratio:. Gibbs Sampling. AlignACE: first statistical motif finder

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Tutorial 4 Comparing Protein Sequences

Tutorial 4 Comparing Protein Sequences. Intro to Bioinformatics. Amino acids were not born equally. Comparing Protein Sequences. Substitution Matrices PAM - Point Accepted Mutations BLOSUM - Blocks Substitution Matrix Advance comparison tools Psi-BLAST Phi-BLAST. Substitution Matrix.

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806 views • 22 slides

Journal club 06/27/08

Journal club 06/27/08. Phylogenetic footprinting. A technique used to identify TFBS within a non-coding region of DNA of interest by comparing it to the orthologous sequences in different species (1988 by Tagle)

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317 views • 19 slides

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