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pRB Binds to the E2F Transcription Factor

pRB Binds to the E2F Transcription Factor. G1 Cyclin CDKs Phosphorylate pRB. Sites of RB Missense Mutations in Tumors. B. A. The A and B domain = pocket = where E2F binds. Tumorigenesis in RB Mutant Mice Requires E2F. Yamasaki et al, Nat. Gen. 18:360 (1998). Proliferation Signals.

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