'P53 mutations' diaporamas de présentation

THE GENETICS OF CANCER

THE GENETICS OF CANCER. DR. MOHAMMED T TAYEB. What Is Cancer?. Neoplasm (Tumour): is abnormal tissue that grows beyond normal cellular control mechanisms. Neoplasms may involve almost any tissue in the body and may be either benign or malignant.

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p53 The Master Guardian

p53 The Master Guardian. Cell cycle control involves several checkpoints and checkpoint (molecular breaking) mechanisms. R point. Three lectures in one slide. p53. Mutations in p53 can be found in half of all tumors. Discovery of p53.

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Exposure Environment Occupation Tobacco Diet Medicines Hormones Cosmetics, hair dyes etc .

Paolo Vineis University of Torino and ISI Foundation EPIC: Molecular markers of carcinogenesis in a large prospective study.

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Biologia e terapia della LLC fludarabina-resistente: ruolo delle mutazioni di TP53

Mediterranean School of Oncology Orvieto, 20-22/11/2009. Biologia e terapia della LLC fludarabina-resistente: ruolo delle mutazioni di TP53. Lorenzo Falchi Marco Gunnellini S.C. di Oncoematologia con Autotrapianto A.O. S.Maria, Terni. Incidence and Anatomy of p53 Mutations.

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p53 gene mutations in human tumor s

p53 gene mutations in human tumor s. 50%. Greenblatt et al. (1995) Cancer Res . 54:4855. p53 and Ink4a are the two most frequently mutated genes in human tumors. The Basic Paradigm of p53 Function. Cellular Stresses (e.g. DNA damage). p53 (high). p53 (low). Apoptosis.

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Relation ship between mutagens and carcinogens

Relation ship between mutagens and carcinogens.

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p53 signaling pathway

p53 is a tumor suppressor protein encoded in humans by the TP53 gene. It had been identified in the 1970s as a binding partner for the SV40 tumor virus oncoprotein large T antigen and an important target for tumor-igenic processes induced by DNA tumor viruses, research in the late 1980s and 1990s validated p53 as a tumor suppressor gene, as p53 mutations were found in up to 50% of human cancers. http://www.creative-diagnostics.com/p53-signaling-pathway.html

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P53 Signaling Pathway

p53 has many mechanisms of anticancer function and plays a role in apoptosis, monitor DNA replication, cell division, and inhibition of angiogenesis. As an anti-cancer promotion agent, it can activate DNA repair proteins when DNA has sustained damage, induce growth arrest by holding the cell cycle at the G1/S regulation point on DNA damage recognition, or initiate apoptosis if DNA damage proves to be irreparable.

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