Parasite proteins - PowerPoint PPT Presentation

Plasmodium Invasive Stages

Plasmodium Invasive Stages. ookinete (motile) mosquito gut epithelial cells sporozoite (motile) mosquito salivary glands hepatocytes merozoite (non-motile) erythrocytes. Merozoite invasion involves specific interactions with the host erythrocyte.

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Malaria Cycle

(Marsh et al, 2004). Malaria Cycle. (Hviid, 2004). Variant Surface Antigens (VSA). Parasite proteins expressed by iRBCs. Each parasite has a repertoire of ~60 var genes for PfEMP1, where each iRBC expresses one type. PfEMP1 regulates the adhesion properties.

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700 views • 15 slides

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