'Pfk 1' diaporamas de présentation

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??? ????. ??? ????. ????? ?? ???? ? ???? ?? ATP ???? ??? ???? ?? ???? ??? Ca ++ ,Fe ++. ? ? ? ? ? ?. ??? ???. ???.

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Glycolysis

Converts: 1 glucose 2 pyruvate Pyruvate can be further metabolized to: (1) Lactate or ethanol (anaerobic) (2) Acetyl CoA (aerobic) Acetyl CoA is further oxidized to CO 2 and H 2 O via the citric acid cycle

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Medical Biochemistry

Medical Biochemistry. Glycolysis/TCA/ETS Robert F. Waters, PhD. Glycolysis(Introduction). Glucose + 2 ADP + 2 NAD + + 2 P i -----> 2 Pyruvate + 2 ATP + 2 NADH + 2 H + Cofactors needed Mg++ for ATP Ca++, Zn++, Cd++ for absorption of glucose. Glycolysis. Anaerobic (Hypoxia)

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Allosteric regulation of enzyme activity

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Regulation of glycolysis and g luconeogenesis

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Coordinated regulation of glycolysis/gluconeogenesis

Coordinated regulation of glycolysis/gluconeogenesis. Regulation of glycolysis. Hexokinase Phosphofructokinase-1 Pyruvate kinase. Hexokinase. There are four isozymes (I, II, III and IV) of hexokinase encoded by four different genes.

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CARBOHYDRATE BIOSYNTHESIS

BC368. Biochemistry of the Cell II. CARBOHYDRATE BIOSYNTHESIS. April 15, 2014. ANABOLISM VS. CATABOLISM. Anabolic and catabolic pathways share many of the same reactions, but irreversible reactions are bypassed. ANABOLISM VS. CATABOLISM.

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Dr.H.MOHAMMAD HANAFI, MBBS (Syd).MS. MEDICAL FACULTY UNAIR

CARBOHYDRATE METABOLISM. Dr.H.MOHAMMAD HANAFI, MBBS (Syd).MS. MEDICAL FACULTY UNAIR. Blog : http//mhanafi123.wordpress.com. INTRODUCTION.

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Possible fates of glucose

Possible fates of glucose. Glycolysis glykys = sweet, lysis =splitting; degradation of glucose the process of the largest carbon flux in most cells sole energy source for many kinds of cells (e.g. erythrocytes, brain, renal medulla, sperm )

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Glycolysis Glycolysis overview Reactions of Glycolysis 1- Hexokinase (Glucose Phosphorylation)

Glycolysis Glycolysis overview Reactions of Glycolysis 1- Hexokinase (Glucose Phosphorylation) - Glucokinase 2- PhosphoFructokinase (PFK-1) - Regulation of PFK-1 Oxidation of glyceraldehyde into 1,3 bisphosphoglycerate Phosphoglycerate Kinase: First ATP generation step

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Regulation of glycolysis

Regulation of glycolysis. Flux through biochemical pathways depends on the activities of enzymes within the pathway For some steps, the reactions are at or near equilibrium in the cell

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Chapter 12: Gluconeogenesis, Pentose Phosphate Pathway, & Glycogen Metabolism

Chapter 12: Gluconeogenesis, Pentose Phosphate Pathway, & Glycogen Metabolism. Glucose catabolism for the production of energy requires a source of Glc . Polysaccharides are degraded and the resulting Glc is stored as glycogen in muscle and liver. glycogen. PPP.

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Coordinated regulation of glycolysis/gluconeogenesis

Coordinated regulation of glycolysis/gluconeogenesis. High blood glucose. Insulin secretion. Synthesis of hexokinase II, PFK-1, pyruvate kinase. Movement of GLUT4 to plasma membrane of myocyte. Activation of insulin-sensitive protein kinase. Activation of protein kinase B. p.903. p.887.

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Bioc 460 Spring 2008 - Lecture 26 (Miesfeld)

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GLYCOLYSIS, GLUCONEOGENESIS, AND THE PENTOSE PHOSPHATE PATHWAY

GLYCOLYSIS, GLUCONEOGENESIS, AND THE PENTOSE PHOSPHATE PATHWAY. Lehninger Ch. 14 BIO 322 Recitation 1 / Spring 2013. OUTLINE. Glycolysis Fates of Pyruvate Regulation of Glycolysis (Chapter 15) Gluconeogenesis Pentose Phosphate Pathway. Fates of Glucose. Glycolysis.

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Chapter 11 (part 2)

Chapter 11 (part 2). Regulation of Glycolysis. Lactate formation. Cori Cycle. Alcohol Fermentation. Free Energy Change in Glycolysis. Hexokinase. Phosphofructokinase-1. Pyruvate kinase. Control Points in Glycolysis. Insulin Induced Exocytosis of Glucose Transporter.

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Glycolysis Rate Limiters

Glycolysis Rate Limiters. LDH Hexokinase PFK-1 NADH/NAD + ratio PHOS Ca 2+ Epinephrine. Lactate Dehydrogenase (LDH). Catalyzes the reaction of pyruvate to lactate Has a low K m resulting in a high affinity for pyruvate Has the highest V max of any glycolytic enzyme

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Phosphofructokinase (PFK-1) regulation

Phosphofructokinase (PFK-1) regulation. Cristian Ascencio and Evan Parker. PFK-1 commits hexoses to glycolysis. The glycolysis product glucose-6-phosphate can be used for both glycolysis and glycogen formation.

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Insights into Regulation

Insights into Regulation.

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Activation of Enzymes

Activation of Enzymes, HIV, and HSPs. NSF Grant # DUE0653234. David Coreas Molecular Biology dvdcoreas@yahoo.com Elena Betancourt Physiology and Neuroscience ebetancourt@ucsd.edu

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