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Proteomics and Glycoproteomics (Bio-)Informatics of Protein Isoforms

Proteomics and Glycoproteomics (Bio-)Informatics of Protein Isoforms

Proteomics and Glycoproteomics (Bio-)Informatics of Protein Isoforms. Nathan Edwards Department of Biochemistry and Molecular & Cellular Biology Georgetown University Medical Center. Outline. Tandem mass-spectrometry of peptides Detection of alternative splicing protein isoforms

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710 views • 45 slides
The Amyloid Hypothesis of Alzheimer Pathogenesis

The Amyloid Hypothesis of Alzheimer Pathogenesis

APP. Self-assembly. Amyloid- b production. tau. neuronal cell death. clinical AD. The Amyloid Hypothesis of Alzheimer Pathogenesis. APP: Chromosomal Location. APP Genetic locus on Chr. 21q21.3. APP is a single copy gene. It exists as one copy per haploid genome.

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682 views • 31 slides
Proteomic Characterization of Alternative Splicing and Coding Polymorphism

Proteomic Characterization of Alternative Splicing and Coding Polymorphism

Proteomic Characterization of Alternative Splicing and Coding Polymorphism. Nathan Edwards Center for Bioinformatics and Computational Biology University of Maryland, College Park. Why don’t we see more novel peptides?.

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267 views • 16 slides
Remove redundant protein isoforms and retain genes with >= 2 protein isoforms

Remove redundant protein isoforms and retain genes with >= 2 protein isoforms

Genes/protein isoforms from Release v31 of Vega (& Release 3 of ASD) database for homo sapiens . 10453 genes with 38172 protein isoforms (8016 genes with 30491 protein isoforms) (>= 2 isoforms per gene). Remove redundant protein isoforms and retain genes with >= 2 protein isoforms.

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114 views • 1 slides

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