Quinols - PowerPoint PPT Presentation

Antitumour Quinols as Novel Inhibitors of Thioredoxin Signalling

◆ 10% Tween/PBS ▲ 200 mg/kg i.p. d 8 ■ 50 mg/kg i.p.d 8-12. Proposed quinol-thioredoxin binding geometry. Cell cycle perturbation by Quinols. NCI mean LC 50 graphs: AW 464 BW 114. Con. 24 h. G1/0. S. G2/M. } Colon. Cell Number. Inhibition of Tx/TR signalling:

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CONCLUSION

Abstract number: 636. 24hrs. 12hrs. A. B.

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CONCLUSION

24hrs. 12hrs.

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CONCLUSION

Novel antitumor quinols: the role of thioredoxin Eng-Hui Chew, Jenny C. Cookson, Charles S. Matthews, Ji-Hong Zhang, Thilo Hagen, Tracey D. Bradshaw, Malcolm F.G. Stevens, Andrew D. Westwell Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, NG7 2RD, UK.

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CONCLUSION

Abstract number: 636. 24hrs. 12hrs. A. B.

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