Samhd1 - PowerPoint PPT Presentation

HIV1- identification of the specific restriction factor SAMHD1

HIV1- identification of the specific restriction factor SAMHD1. Monsef Benkirane Institut de Génétique Humaine Montpellier. Dendritic cells are refractory to HIV-1 infection. X. Does HIV-1 escapes innate immune recognition by avoiding productive infection of Dendritic cells?.

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DC Goldstone et al . Nature 000 , 1 - 4 (2011) doi:10.1038/nature10623

SAMHD1 is allosterically activated to cleave dATP, dCTP and TTP by dGTP. DC Goldstone et al . Nature 000 , 1 - 4 (2011) doi:10.1038/nature10623.

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