'Sequence comparison' diaporamas de présentation

Alignment of large genomic sequences

Alignment of large genomic sequences. Fragment-based alignment approach ( DIALIGN ) useful for alignment of genomic sequences. Possible applications: Detection of regulatory elements Identification of pathogenic microorganisms Gene prediction. The DIALIGN approach.

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An Introduction to Bioinformatics

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Data bases ( Biosequences, Structures, Genomes, DNA Chips, Proteomics, Interactomics ) Design

BIOINFORMATICS. Data bases ( Biosequences, Structures, Genomes, DNA Chips, Proteomics, Interactomics ) Design Curation Data Mining. Computational Biology Tools for: Sequence analysis Structure prediction Docking Structural genomics Functional genomics Proteomics Interactomics.

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A lignment Class II

A lignment Class II. We continue where we stopped last week: Dynamic programing. a gene. transcription. pre-mRNA. splicing. mature mRNA. translation. protein. Reminder -Structure of a genome. Pairwise Sequence Alignment. Example Which one is better?. HEAGAWGHEE. PAWHEAE. HEAGAWGHE-E.

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CS5263 Bioinformatics

CS5263 Bioinformatics. Lecture 1: Introduction. Outline. Administravia What is bioinformatics Why bioinformatics Topics in bioinformatics What you will & will not learn Introduction to molecular biology. Student info. Your name Email Enrollment status Academic background Interests.

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Sequence Analysis and Function Prediction

Sequence Analysis and Function Prediction. Limsoon Wong. Very Brief Intro to Sequence Comparison/Alignment. Motivations for Sequence Comparison. DNA is blue print for living organisms Evolution is related to changes in DNA

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Class 2: Basic Sequence Alignment

Class 2: Basic Sequence Alignment. Sequence Comparison. Much of bioinformatics involves sequences DNA sequences RNA sequences Protein sequences We can think of these sequences as strings of letters DNA & RNA: alphabet of 4 letters Protein: alphabet of 20 letters.

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BIOINFORMATICS Structures

BIOINFORMATICS Structures. Mark Gerstein, Yale University bioinfo.mbb.yale.edu/mbb452a (last edit in Fall '05). What Structures Look Like? Structural Alignment by Iterated Dynamic Programming RMS Superposition Rotating and Translating Structures Scoring Structural Similarity.

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Sequence comparison: Significance of similarity scores

Lecture 5A Tuesday, January 22, 2008. Sequence comparison: Significance of similarity scores. Genome 559: Introduction to Statistical and Computational Genomics Prof. William Stafford Noble. One-minute responses.

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Current Challenges in Bioinformatics

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Protein Structure and Function Prediction

Protein Structure and Function Prediction. Predicting 3D Structure. Outstanding difficult problem. Comparative modeling (homology) Fold recognition (threading). Based on Sequence. Based on Secondary Structure. Based on Sequence. Comparative Modeling.

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CS 7010: Computational Methods in Bioinformatics (course review)

CS 7010: Computational Methods in Bioinformatics (course review). Dong Xu Computer Science Department 271C Life Sciences Center 1201 East Rollins Road University of Missouri-Columbia Columbia, MO 65211-2060 E-mail: xudong@missouri.edu 573-882-7064 (O) http://digbio.missouri.edu.

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Hidden Markov Models For DNA Sequence Alignment

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Multiple sequence comparison (MSC)

Multiple sequence comparison (MSC). Reading: Setubal/Meidanis, 3.4 Gusfield, Algorithms on Strings, Trees and Sequences, chapter 14. Why care about similarity?. Similar sequences have similar structure. Similar structure -> similar sequence?. No, the converse is not true!

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Chapter 10: Studying the Text

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Bioinformatics CSM17 Week 7: Molecular Analysis

Bioinformatics CSM17 Week 7: Molecular Analysis. Sequence comparison Molecular characters Homoplasy and convergence Multiple Sequence Alignment Cladograms from Molecular Data. Molecular data. A T G C A T G C Sense Strand (Partner) | | | | | | | | A U G C A U G C Messenger RNA

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Function preserves sequences

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Sulfolobus Tokodaii

Sulfolobus Tokodaii. A genome from Japan. By Patricia Ueng. Sulfolobus Tokodaii. A member of the archaea (third branch of life next to eukaryotes and bacteria. It was isolated from Beppu hot springs in Kyusyu, Japan It lives in 80 C and pH 2 and 3, an acidic and sulfur-rich environment.

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