Ser 195 - PowerPoint PPT Presentation

Serine Protease and Its Inhibitor

Serine Protease and Its Inhibitor. By 第四組. 酵素基本反應機制. 三個基本動作： 1 、 Orientation 空間方向 2 、 Acid-base transfer 化學轉移 3 、 Bond Strain 構形扭曲. 以上三種方式同時發生稱為協同式酵素催化 (concerted set) 例： Carboxypeptidase A ，羧肽酶若先後依序發生，稱順序式酵素催化 (sequential mechanism) 例： Chymotrypsin ，胰凝乳蛋白酶.

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CHYMOTRYPSIN

INTRO. CHYMOTRYPSIN. MISSION:. To cleave peptide amide bonds of protein in small intestine. Cleave carboxyl terminus of large nonpolar or aromatic side chains i.e. Tyr, Trp , Phe , and Met Initial general acid-base catalysis Covalent nucleophilic catalysis. STRATEGY:. Protease

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