Smad4 mutation - PowerPoint PPT Presentation
SMAD4/DPC4: A Tumor Suppressor James Brooks March 23 rd , 2006
SMAD4/DPC4: A Tumor Suppressor James Brooks March 23 rd , 2006. Found on chromosome 18 in humans, encodes 11 exons. A 552 amino acid protein found in the cytoplasm. SMAD Structure: MH1 and MH2 Domains. SMAD proteins exist as homo-oligomers.
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Smad4 (Dpc4) in Colon Cancer
Smad4 (Dpc4) in Colon Cancer. Elizabeth Jarvis March 22, 2007. Objectives:. I. Cell Biological Role of Smad4 II. Biological Role of Protein (What does it do for the Organism?) III. Connection to Cancer Colon and Pancreatic. I. Cell Biological Role of Smad4. Smads.
By sissy
Smad4 (Dpc4) in Colon Cancer
Smad4 (Dpc4) in Colon Cancer. Elizabeth Jarvis March 22, 2007. Objectives:. I. Cell Biological Role of Smad4 II. Biological Role of Protein (What does it do for the Organism?) III. Connection to Cancer Colon and Pancreatic. I. Cell Biological Role of Smad4. Smads.
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Recherches associées pour Smad4 mutation
Smad4
I. cAMP. I. R-SMAD. c-jun. R-SMAD. Smad4. . p300 /CBP. p300 /CBP. p300 /CBP. Phospho-Serine. Phospho-Threonine. TGF- b. IFN- g. TNF- a. TGF- b. PGE 2. IFN- g. II. II. cytoplasm. SMAD7. FKBP12. JNK. SARA. JAK1. R-SMAD. Smad4. Smurf1/2. PKA. R-SMAD. Smad4. CREB.
Mutation
Mutation. دانشگاه علوم پزشكي وخدمات بهداشتي درماني تهران. Dr. Parvin Pasalar Tehran University of Medical Sciences. Mutation. Definition: An un- repaired damages to DNA Causes: It may be spontaneous or induced because of different agents Classifications:
Mutation
Mutation. Bellwork. Explain the role of mRNA, tRNA, and rRNA in translation. Objectives. Define mutation Explain the difference between base substitution and frameshift mutation Explain how mutations affect living things. Key Terminology. Mutation Base substitution Point mutation
MUTATION
MUTATION. SELECTION. POPULATIONS. MIGRATION. DRIFT. Phenotypic Evolution: Process. +. —. +/ —. —. Assume: a single autosomal locus with 2 alleles. Frequency ( A ) = p Frequency ( a ) = q Suppose that A mutates to a at rate u : A a = u
Mutation
Mutation. Mutation. Means change Definition: An event that gives rise to an alteration in the genotype It also can be the change itself Mutation does not mean “bad” Mutations are IMPORTANT for a variety of reasons. Mutation ‘Levels’. DNA Level Chromosomal Level Genome Level.
Mutation
Mutation. Mutation. Means change Definition: An event that gives rise to an alteration in the genotype It also can be the change itself Mutation does not mean “bad” Mutations are IMPORTANT for a variety of reasons. Mutation ‘Levels’. DNA Level Chromosomal Level Genome Level.
Mutation
Mutation. Dan Graur.
Mutation
Mutation. So far, our data abstractions consists of the following: Constructors Selectors/Accessors Operations Contract Once a data object is created, it never changes. Today, we’ll talk about how to alter the internal structure of data objects. Why Mutation?.
Mutation
Mutation. Higher Biology. Mutation. Change in structure or amount of an organism’s genetic material Change in genotype produces change in phenotype = mutant 2 types of mutation Chromosome mutation Change in structure of one chromosome. Chromosome mutations. Change in chromosome number