SMAD 4/ DPC4 and Colon Cancer. Morphological and molecular analyses of Smad4-/- embryos (Right) and their littermate controls (Left). . Yang X et al. PNAS 1998;95:3667-3672. References. Beretta G, Braud F, Kildani B, et. al. (2010) Colon Cancer. Oncology/Hematology 74(2), 106- 133
By ciqalaSmad4 (Dpc4) in Colon Cancer. Elizabeth Jarvis March 22, 2007. Objectives:. I. Cell Biological Role of Smad4 II. Biological Role of Protein (What does it do for the Organism?) III. Connection to Cancer Colon and Pancreatic. I. Cell Biological Role of Smad4. Smads.
By sissySmad4 (Dpc4) in Colon Cancer. Elizabeth Jarvis March 22, 2007. Objectives:. I. Cell Biological Role of Smad4 II. Biological Role of Protein (What does it do for the Organism?) III. Connection to Cancer Colon and Pancreatic. I. Cell Biological Role of Smad4. Smads.
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I. cAMP. I. R-SMAD. c-jun. R-SMAD. Smad4. . p300 /CBP. p300 /CBP. p300 /CBP. Phospho-Serine. Phospho-Threonine. TGF- b. IFN- g. TNF- a. TGF- b. PGE 2. IFN- g. II. II. cytoplasm. SMAD7. FKBP12. JNK. SARA. JAK1. R-SMAD. Smad4. Smurf1/2. PKA. R-SMAD. Smad4. CREB.
Smad4 (Dpc4) in Colon Cancer. Elizabeth Jarvis March 22, 2007. Objectives:. I. Cell Biological Role of Smad4 II. Biological Role of Protein (What does it do for the Organism?) III. Connection to Cancer Colon and Pancreatic. I. Cell Biological Role of Smad4. Smads.
Supplementary data. S Figure 1. Microarray SMAD4 immunohistochemical staining in breast carcinoma and surrounding normal breast epithelia. A. B.
SMAD4/DPC4: A Tumor Suppressor James Brooks March 23 rd , 2006. Found on chromosome 18 in humans, encodes 11 exons. A 552 amino acid protein found in the cytoplasm. SMAD Structure: MH1 and MH2 Domains. SMAD proteins exist as homo-oligomers.