MEEC. A. TGF- b (0.25 ng/ml). B. TGF- b (5 ng/ml). BAEC. - TGF- b. No stim. caALK1. caALK5. Smad7. Marker. H 2 O. LacZ. +TGF- b. 400 MOI F-Smad7. 1000 MOI LacZ. 1000 MOI F-Smad7. 400 MOI LacZ. 0.25. 0.25. PS1. 0.1. 0.5. 2.5. 0.1. 0.5. 2.5. 0.5. 1.5. 0.5. 1.5.
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Smad7-induced b -catenin degradation alters epidermal appendage development. Han, G. et al., 2006, Dev Cell. Diagrammatic Depiction of the Hair Follicle Stem Cell Niche and the Cutaneous Lineages Deriving from the Bulge Stem Cells Adapted from Alonso and Fuchs, 2003.