T cell activation - PowerPoint PPT Presentation

Chapter 43: Internal Defense

Chapter 43: Internal Defense. Immune Response – fight antigens. Nonspecific (innate)– general Specific (adaptive or acquired) – tailor made Antibodies. Fig. 43-2. Pathogens (microorganisms and viruses). Barrier defenses: Skin Mucous membranes Secretions. INNATE IMMUNITY. •.

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T Cells and Immunity

T Cells and Immunity. Antigen Recognition T cells only recognize antigens that are bound to glycoproteins in plasma membranes . T Cells and Immunity. MHC Proteins The membrane glycoproteins that bind to antigens Genetically coded in chromosome 6 The major histocompatibility complex (MHC)

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T Cell Maturation and Activation

T Cell Maturation and Activation February 15, 2001 Outline T Cell Maturation Early development in the thymus Positive Selection and Negative Selection CD4 + T Cells vs. CD8 + T Cells T Cell Activation Signal Transduction/Gene Expression Costimulation Expansion vs. Anergy

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