'Target proteins' diaporamas de présentation

Molecules and the Human Body Module Leader Dr Graham Ladds Warwick Medical School

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Cell Division and Genetics

Cell Division and Genetics. Chapters: 12-15. Why do we need cell division?. 2 REASONS: Growth and maintenance Reproduction. Cell Cycle Overview. http://gaskinsanatomy.wikispaces.com/file/view/CellCycle_L.jpg/252096666/CellCycle_L.jpg. The Cell Cycle Control System.

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US Veterinary Immune Reagent Network

Project Directors Cynthia Baldwin, University of Massachusetts Amherst Eva Bengten , University of Mississippi Medical Center

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Expression Vector Expression of cloned genes produces large quantities of protein

Expression Vector Expression of cloned genes produces large quantities of protein. Components of expression vector replication origin polylingker (MRS or MCS) Selective marker promoter operator ribosome binding site gene encoding repressor.

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Meeting

Meeting. 26 th September, 2013. What are drugs?. Organic small molecules Bind to bio-molecular targets (usually refer to proteins) to activate/inhibit their functions. Drugs often affect multiple targets. Target (Protein). Drug (Compound) (Ligand).

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Cells receive signals from 1. Physical environment

Chapter 15 Baboon text Cell Signaling and Communication 15.1 What Are Signals, and How Do Cells Respond to Them?. Cells receive signals from 1. Physical environment Ex: light, temperature, touch, sound and chemicals 2. Other cells- primarily in the form of chemicals and touch.

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Signal Transduction

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Transplantation David Straus

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Proteomics Technologies with a Focus on Mass Spectrometry

Proteomics Technologies with a Focus on Mass Spectrometry. John Carrithers. Presentation Goals. Increase understanding of the Proteome Share some of the proteomic technologies at work Provide basis theory of mass spectrometry in the field of proteomics

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FDR Thresholding

FDR Thresholding. Caleb J. Emmons. What is FDR?. If decoy proteins are present. # decoy proteins identified. Protein FDR =. # target proteins identified. # spectra from decoy proteins. Peptide FDR =. # spectra from target proteins. The FDR Browser. How does FDR Thresholding work?. 5.

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FDR Thresholding

FDR Thresholding. Caleb J. Emmons. What is FDR?. If decoy proteins are present. # decoy proteins identified. Protein FDR =. # target proteins identified. # spectra from decoy proteins. Peptide FDR =. # spectra from target proteins. The FDR Browser. How does FDR Thresholding work?. 5.

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Polishing Your Prose

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In silico Study of Target Proteins for Mycobacterium tuberculosis

The completion of the genome of pathogens and the human has provided data that can be utilized to design vaccines and drug targets. One of the recently adopted strategies for drug designing is based on comparative genomics approach, it gives a set of genes that are likely to be essential to the pathogen but absent in the host. By performing homology searches and structural modeling, we can determine which of these proteins can provide novel targets for designing functional inhibitor compounds active against bacteria.

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targeted protein degradation

In mammalian cells, protein degradation is mainly carried out by the ubiquitin-proteasome system to dispose damaged or excess proteins. Ubiquitin can be attached to the substrate protein through a series of enzymatic reactions leading to the covalent bonding between the C-terminal glycine of ubiquitin and the lysine residue of the substrate. Ubiquitin-tagged proteins are eventually recognized and destructed by proteasome. In spite of the high complexity of ubiquitin system, it is not surprising that some components or processes in this system could provide for promising therapeutic targets to treat a variety of diseases, including cancer and neurodegeneration. One good example is the E3 ligases, which regulate the attachment of ubiquitin tags to the substrate protein for subsequent degradation.

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Molecular Biological Detection

With the continuous development of life science and chemistry, people's understanding of organisms has been gradually deepened to the micro level.

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EXPERIMENTAL

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Protein Ubiquitination

Ubiquitin is an about 8.5 kDa polypeptide consisting of 76 amino acids that is appended to the ?-NH2 of lysine in target proteins via the C-terminal glycine of ubiquitin.

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