'Telomere shortening' diaporamas de présentation

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MCB 135K: Discussion

MCB 135K: Discussion. February 7, 2005 GSI: Laura Epstein. Topics. Epidemiology of Aging Telomeres. EPIDEMIOLOGY OF AGING. THE STUDY OF THE AGE-RELATED DISTRIBUTION AND CAUSES OF DISEASE, DISABILITY, AND MORTALITY IN HUMAN POPULATIONS. EPIDEMIOLOGY OF AGING. WHY IMPORTANT?

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Bacterial DNA replication

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Cellular Senescence What is it? What causes it? Why is it important (cancer and aging)?

Cellular Senescence What is it? What causes it? Why is it important (cancer and aging)?. Cellular Senescence What is it? Response of normal cells to potentially cancer-causing events The senescence response is an anti-cancer mechanisms that prevents

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Telomeres and senescence II

Telomeres and senescence II. A&S300-002 Jim Lund. Telomeres in mice. Lab strains of mice have very long telomeres. 30-40kb telomeres. Tert knock-out mice: Normal for four generations as their telomeres shorten, Premature aging phenotypes present in the 5th and generation.

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Contents

Contents. Hepatocellular carcinoma (HCC) ??? ?? telomere ?? 1-1. ?? ??? ??? ?? 1-2. telomere 1-3. Animal model. End-fusion. Titia de Lange, 2005. Telomere. ??? ??? ???? ????? ??? ?? . ??? T ? G ? ???. Telomere shortening.

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MCB 135K: Discussion

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MCB 135K: Discussion

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TELOMERES What are they? Why are they important?

TELOMERES What are they? Why are they important? Telomere shortening and the end-replication problem Telomerase Telomere hypothesis of aging. Telomeres Ends of linear chromosomes. Centromere. Telomere. Telomere. Repetitive DNA sequence (TTAGGG in vertebrates) Specialized proteins

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TELOMERES What are they? Why are they important?

TELOMERES What are they? Why are they important? Telomere shortening and the end-replication problem Telomerase Telomere hypothesis of aging. Telomeres Ends of linear chromosomes. Centromere. Telomere. Telomere. Repetitive DNA sequence (TTAGGG in vertebrates) Specialized proteins

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Telomerase

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