Thioredoxin - PowerPoint PPT Presentation

Assessment of Oxidative Stress

Assessment of Oxidative Stress. Oxidative stress involves in various diseases. Aging. Cancer. Inflammation. Arteriosclerosis. Ischemic Reperfusion. Mucosa of the Gut Disease. Hepatic Disease. Diabetes. Cardiac Disease (cardiac infarct etc.). Respiratory Disorder. Renal Disease.

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2 lead compounds identified from 2 novel chemical series:- AW 464 (1 st series)

2 lead compounds identified from 2 novel chemical series:- AW 464 (1 st series) AJM 290 (2 nd series) Potent, selective in vitro and in vivo activity: renal, colon, breast, melanoma cell lines Evidence suggests activity associated with inhibition of HIF signalling

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379 views • 20 slides

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