'Tsc1 2' diaporamas de présentation

GENOMIC ANALYSIS OF OVER 400 SARCOMAS

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HCVM

HCVM. Member of b -herpesvirus family >200 ORFs Genes are expressed in a regulated cascade Some fulfill regulatory functions pUL38 expression during early phase pUL38 blocks apoptosis. http://www.abbottdiagnostics.co.uk. Tuberous Sclerosis Complex. Autosomal dominant disorder

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Growth factors

Growth factors. nutrients. translation. Ad VA RNAs. PKR. p70S6K. Ad E4-ORF4. PIP3. eIF-4E. EIF2 a. PTEN. PDK1. RHEB. mTOR. 4E-BP1. PERK. TSC1/2. PI3K. ER stress. Ca 2+. AMPK. Cyt c. Ad E4-ORF1. Apoptosis/cell death. AKT (PKB). Ras. Caspase cascade. Raf. GSK3. Bax/Bak.

234 views • 1 slides