U0126 - PowerPoint PPT Presentation

RAS

RAS. ?. RAL-GEF. PI3’K. RAF. proliferation. U0126 PD98059 PD184352 (CI-1040). MEK. AKT. ERK. proliferation survival. proliferation / differentiation survival migration. Structures of MEK Inhibitors. PD098059. U0126. PD184352 (CI-1040). PD0325901.

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12. Uninfected. Uninfected. *. 35. *. + 7.13. + 7.13. 30. 10. 25. 8. #. *. 20. Percentage of elongated cells. Number of spheroids. 6. #. #. #. 15. *. *. *. 4. #. #. 10. #. #. #. 2. #. 5. 0. 0. -. -. PD. Ctrl. SP. U0126. Ctrl. PD. SP. U0126. SP+PD.

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