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Sequence comparison

Sequence comparison

Sequence comparison. based on Chapter 4 Lesk, Introduction to Bioinformatics. Contents. Motivation Sequence comparison and alignments Dot plots Dynamic programming Substitution matrices Dynamic programming: Local and global alignments and gaps BLAST Significance of alignments

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1.61k views • 107 slides
Computational Genomics Lecture #3a (revised 24/3/09)

Computational Genomics Lecture #3a (revised 24/3/09)

Intro to ML and Scoring functions PAM and BLOSUM AA scoring matrices. Computational Genomics Lecture #3a (revised 24/3/09). Background Readings : Section 2.7, 2.8 in Biological Sequence Analysis , Durbin et al., 2001.

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272 views • 27 slides
BLAST

BLAST

BLAST. Sequence alignment, E-value & Extreme value distribution. Database searching. Using pairwise alignments to search databases for similar sequences. Query sequence. Database. Database sizes. PDB: 169,581 sequences; 39,601,444 total letters

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400 views • 26 slides
BIOMETRICS

BIOMETRICS

BIOMETRICS. Module Code: CA641 Week 11- Pairwise Sequence Alignment. Outline. Why should one do sequence comparison ? Dynamic programming alignment algorithms global alignment (Needleman- Wunsch ) local alignment (Smith-Waterman ) Heuristic alignment algorithms : FASTA , BLAST

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468 views • 20 slides
BLAST

BLAST

BLAST. Anders Gorm Pedersen & Rasmus Wernersson. Database searching. Using pairwise alignments to search databases for similar sequences. Query sequence. Database. Database searching.

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476 views • 17 slides

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