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A Novel Approach on Thalidomide and their analogues with their therapeutic uses and clinical application

A Novel Approach on Thalidomide and their analogues with their therapeutic uses and clinical application

Thalidomide a N phthalimido glutarimide, C13 H10 N2 O4 , is a glutamic acid derivative initially introduced as a sedative hypnotic nearly forty years ago. It was withdrawn following numerous reports linking it to a characteristic pattern of congenital abnormalities in babies born to mothers who used the drug for morning sickness. It has gradually been re introduced into clinical practice over the past two decades, albeit under strict regulation, since it was found to be broad spectrum of anti cancer activity. Anti tumor activity of thalidomide may be related to a number of known properties, including anti tumor necrosis factor TNF a and T cell co stimulatory and anti angiogenic activities. Nanoemulsions of thalidomide were prepared in the form of intravenous injection for the treatment of cancer. The therapeutic potential of thalidomide provided motivation to develop more effective derivatives with considerably reduced toxicity. There are two types of thalidomide's immunomodulatory IMiDs analogs are lenalidomide and pomalidomide represent a novel class of compounds with numerous effects on the immune system. These analogs are thought to mediate the anticancer and anti inflammatory effects observed in humans. Thalidomide is currently approved for the treatment of dermal reaction to leprosy and is currently in phase III trials for multiple myeloma MM . IMiDs inhibit the cytokine's tumor necrosis factor a TNF a , interleukins IL 1 a, 6, 12, and granulocyte macrophage colony stimulating factor GM CSF . The repression of the tumor necrosis factor a TNF a expression is the crucial factor of many of the anti inflammatory properties of thalidomide. Rahul Singh Kushwaha | Pankaj Chasta | Aziz Ahmed | Dr. Kaushal K. Chandrol "A Novel Approach on Thalidomide and their Analogues with their Therapeutic uses and Clinical Application" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23233.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/23233/a-novel-approach-on-thalidomide-and-their-analogues-with-their-therapeutic-uses-and-clinical-application/rahul-singh-kushwaha

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Miracle of Herbals and Natural Products in Treatment and Regulation of Obesity

Miracle of Herbals and Natural Products in Treatment and Regulation of Obesity

The perfect anti obesity sedate would deliver supported weight misfortune with negligible side effects. The instruments that direct vitality adjust have significant built in repetition, overlap considerably with other physiological capacities, and are affected by social, hedonic and psychological components that restrain the viability of pharmacological intercessions. It is therefore unsurprising that anti obesity medicate revelation programs have been littered with untrue starts, failures in clinical improvement, and withdrawals due to unfavorable impacts that were not fully appreciated at the time of dispatch. Drugs that target pathways in metabolic tissues, such as adipocytes, liver and skeletal muscle, have appeared potential in preclinical considers but none has however come to clinical development. Later enhancements within the understanding of peptidergic flagging of starvation and satiety from the gastrointestinal tract intervened by ghrelin, cholecystokinin CCK , peptide YY PYY and glucagon like peptide 1 GLP 1 Himangshu Jyoti Hazarika | Aziz Ahmed | Kaushal K. Chandrul "Miracle of Herbals and Natural Products in Treatment and Regulation of Obesity" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23549.pdf Paper URL: https://www.ijtsrd.com/pharmacy/other/23549/miracle-of-herbals-and-natural-products-in-treatment-and-regulation-of-obesity/himangshu-jyoti-hazarika

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Child Malnourishment in India and it's Scientific Solutions

Child Malnourishment in India and it's Scientific Solutions

Malnutrition in children is responsible for more than 3.5 million deaths every year and is thus a serious threat globally 1 . Despite the rapid economic growth and development of India, it remains burdened with an unfinished agenda of undernutrition. Estimates by the National Family Health Survey NFHS show that 48 , or 61 million, under five age group children in the country are stunted they have low height for their age 43 , or 53 million, are underweight and nearly 20 , or 25 million, are wasted low weight for height 2 . Its imperative to focus on production diversity as well as food fortification at a macro level e.g. millets are 4 5 times more nutritious than rice and wheat in terms of proteins minerals and vitamins 3 . The ready to use food supplement RUTF is equivalent to F 100 formula milk based used at hospitals across India but is instead made in a paste that can be safely given to a child at home. Besides, the initiatives taken by the Government of India some innovative ideas proposed can also be practiced. More than half of the malnourishment is due to poor sanitation than lack of nutrition so awareness and cleanliness measures on a large scale play an important role as well. Misbah Khan "Child Malnourishment in India & its Scientific Solutions" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd23836.pdf Paper URL: https://www.ijtsrd.com/biological-science/biotechnology/23836/child-malnourishment-in-india-and-its-scientific-solutions/misbah-khan

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