'Xbp 1' diaporamas de présentation

Molecular Chaperones

Molecular Chaperones. The Hsp70 Super-family. Pathways For Protein Folding. Protein Folding in Cells Occurs in a Crowded Environment where Misfolding & Aggregation are Favored. Hsp 70 Family Proteins Assist Protein Folding in an Energy Dependent Process.

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Major Claims

Major Claims. IRE1 initiates an XBP-1 independent pathway during the unfolding protein response IRE1 nuclease has a broader range of substrates than XBP-1 IRE1 mediates the rapid degradation of a subset of mRNA Degradation is dependent on ER localization and peptide sequence. No treatment.

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The Unfolded Protein Response in C. Elegans

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Attractive

A. Attractive. '. g. e. g. c. '. c. b. b. d. V. f. f. f. '. f. '. b. d. c. V. b. '. c. g. e. '. B. Attractive. '. g. e. g. c. '. c. b. b. N. d. f. f. f. '. f. '. b. d. c. N. b. '. c. g. e. '. C. Repulsive. '. g. e. g. c. '. c. b.

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CE Richardson et al. Nature 463 , 1092-1095 (2010) doi:10.1038/nature08762

XBP-1 is required for development and survival during pathogen-independent constitutive activation of PMK-1. CE Richardson et al. Nature 463 , 1092-1095 (2010) doi:10.1038/nature08762.

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CE Richardson et al. Nature 463 , 1092-1095 (2010) doi:10.1038/nature08762

XBP-1 is required for C. elegans development and survival on P. aeruginosa. CE Richardson et al. Nature 463 , 1092-1095 (2010) doi:10.1038/nature08762.

92 views • 1 slides