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Synthesis and In vitro Antimycobacterialactivity of Some Novel Pyrrolo[1,2-A]Pyrazine Incorporated Indolizine Derivative

Synthesis and In vitro Antimycobacterialactivity of Some Novel Pyrrolo[1,2-A]Pyrazine Incorporated Indolizine Derivative

The accumulating pharmacological importance of drug resistant pathogens has lent auxiliary urgency to new anti-tubercular compound development. In this regard, a novel series of pyrrolo [1,2-a]pyrazine incorporated indolizine derivatives have been synthesized, characterized by using spectral data and screened for in vitro antimycobacterial activity. The anti-tubercular activity of the synthesized compounds (7a-p) was determined by microplate alamar blue assay and the outcomes were screened against Mycobacterium tuberculosis H37Rv strain. Compounds 7a-p exhibited good to potent anti-tubercular activity when compared with the standard first line anti-tuberculosis drugs (ciprofloxacin, pyrazinamide and streptomycin). Some of the tested compounds exhibited highest inhibitory activity at 1.6 u00b5g/ml minimal inhibition concentration.

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Design, Synthesis of New Iso-oxazoline Containing Iminothiazolidinone and its Antibacterial Activity

Design, Synthesis of New Iso-oxazoline Containing Iminothiazolidinone and its Antibacterial Activity

We have synthesized novel 2-(4-(3a,4,5,6,7,7a-hexahydro-4,7-methanobenzo[d]isooxazol-3-yl)phenyl) imino)-3-methylthiazolidin-4-one and its benzilidine derivatives in good yields, by clubbing substituted Isooxazoline and 4-Iminothiazolidinone. All the synthesized compounds were characterized using IR and NMR spectroscopy. The results of the characterization are in agreement with the structures of compounds and tested for its antibacterial and antifungal activity against various strains like Staphylococcus aureus (NCLM 2602), Bacillus subtilis (NCLM 2458), Escherichia coli (NCLM 2809), Aspergillus niger (NCLM 617), Rhizopus ostoyae NCLM 1299) by using antibacterial susceptibility test. All the newly synthesized compounds possess moderate to good antibacterial activity.

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53 views • 5 slides

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