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Sex Determination and Sex-Linked Traits

Sex Determination and Sex-Linked Traits. Chapter 4. Outline. Sex Determination Different Karyotypes sry gene and maleness Sex Linked Traits Barr Bodies. 1. Chromosomal Sex determination Systems. XX-XO XX-XY ZZ-ZW Haplodiploidy.

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Sex Determination and Sex-Linked Traits

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  1. Sex Determination and Sex-Linked Traits Chapter 4

  2. Outline • Sex Determination • Different Karyotypes • sry gene and maleness • Sex Linked Traits • Barr Bodies

  3. 1. Chromosomal Sex determination Systems XX-XO XX-XY ZZ-ZW Haplodiploidy

  4. A closer look at 2 different systems of sex determination

  5. 2. Genetic Sex Determining Systems • Genic Balance Sex Determination • Environmental Sex Determination drosophila Slipper limpet

  6. Drosophila: genic balance * autosome= any non-sex chromosome

  7. Human Karyotypes Klinefelter Syndrome Non-disjunction NORMAL Turner Syndrome

  8. Maleness • Determination of maleness is due to sry gene of Y chromosome • Expression of gender is more complex than just sry gene. • Example: androgen insensitivity • Xy genotype • Many female characteristics!

  9. Sex Linked (X-linked) Traits (3 examples) • Human Color Blindness

  10. Sex Linked (X-linked) Traits • White eye Drosophila

  11. Hemophilia Pedigree of hemophilia XhY x XHXh ½ XH ½ Xh ¼ XHXh ¼ XhXh ½ Xh ½ Y ¼ XHY ¼ XhY

  12. Barr Bodies & X-Inactivation • What are they? • Why does it occur?

  13. Number of Barr Bodies in Human Cells

  14. X-Inactivation in cats Tortoiseshell Color

  15. Y-Linked Inheritance • Few genes on Y chromosomes • Few examples of known Y linked traits to date

  16. The End

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