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Georgetown University

Explore a network facilitating multi-center clinical trials for rare diseases like Adrenoleukodystrophy, optimizing data sharing and analysis through digital MRI networks. Learn about the project's development, data transmission tests, and the future of medical research at Georgetown University.

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Georgetown University

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  1. Georgetown University Chuck Wolfe wolfec@georgetown.edu

  2. Campus Description • Medical Center (GUMC) • 8 Research Buildings • Main Campus • 32 Campus Buildings including Dorms,Staff and Academic • 6 Ancillary Buildings connected via 100Mbps

  3. GUMC Network • Gigabit Core • Building Distribution Frames (BDFs) have a Dual Gigabit connection to the core • Floor Switches have a Gigabit connection to the BDFs • User provided with 10/100 connection

  4. Main Campus Network • OC-12 ATM core • Server Farm has OC-12 connections to the core • BDFs have dual OC-3 connections to the core • Floor Switches have 100-200Mbps links to the BDFs • User provided with 10 or 10/100 connection

  5. Remote Site Connections • OC-3 ATM • Frame-Relay • FNS (10Mbps) • T-1

  6. Internet 2 • Connected via ATM utilizing Unspecified Bit Rate (UBR) • Primary connection to Abilene through MAX • Currently being used to test teleradiology application in the study of ALD

  7. What is ALD? • Adrenoleukodystrophy is a rare genetic disorder that is often fatal in young boys. • It affects 1 in 20,000 people world-wide • A neurological disorder that destroys the myelin in the brain • Myelin insulates nerves and allows conduction of impulses between parts of the body • MRI permits early detection of nervous system damage and is a sensitive indicator of disease progression

  8. Why are Multi-Center Clinical Trials Needed • No institution has enough patients to perform a randomized control study • ALD trained physicians are few due to the rarity of disease • Sharing of film images is difficult in an analogue world

  9. Solution – Digital ALD MRI Network • Multiple sites can send data to a centralized database • Consolidation of data provides sufficient patient pool for therapy evaluation • ALD trained physicians have immediate remote access to the exams

  10. Project Description • Development of DICOM network • DICOM database resides at KKI • Receives MRI studies from multiple institutions in US and world-wide • Permits query/retrieve of studies by ALD trained physicians for review • Utilizes secure technologies to ensure patient confidentiality and data integrity • Works over standard Internet and NGI

  11. UMN –ISIS – KKI • Requested data from UMN over NGI • Upon receipt, immediately sent it to KKI over standard Internet • Recorded transmission times • Ran the test 7 times • Results: • ISIS – UMN averaged 242.5 seconds • ISIS – KKI averaged 2062.2 seconds

  12. Transmission Time UMN – ISIS – KKI(Seconds) ISIS – KKI 45 miles UMN – ISIS 1100 miles

  13. ISIS – KKI • Requested studies from KKI DICOM server to ISIS • Ran the test 78 times over standard Internet • Ran the test 83 times over NGI

  14. NGI =296 n=83 Internet =67 N=78 Throughput: Internet vs. NGI

  15. Results • Moving digital images is better than using film for sharing information • Standard Internet is unpredictable for moving large data sets • NGI supports real-time teleradiology • Future enhancements of the NGI will be evaluated

  16. Current Projects at GU • Wireless Testing with authentication to LDAP • VoIP • Multicasting • QOS • Gigabit Connection to the Internet

  17. Thanks to Betty Levine and MaryLou Ingeholm in ISIS for ALD testing info

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