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NIAID W orkshop on Grantsmanship , Funding, and Peer Review

NIAID W orkshop on Grantsmanship , Funding, and Peer Review

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NIAID W orkshop on Grantsmanship , Funding, and Peer Review

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  1. NIAID Workshop on Grantsmanship, Funding, and Peer Review

  2. NIH Structure and Grantsmanship Alison Deckhut Augustine, Ph.D. Basic Immunology Branch Division of Allergy, Immunology and Transplantation National Institute of Allergy and Infectious Diseases

  3. Presentation Outline • NIH Structure and Grantsmanship(Alison) • Funding Opportunities (Lawrence Prograis, MD) • Grant Application Process/Peer Review (B. Duane Price, PhD)

  4. NIH – 27 Institutes and Centers Office of the Director National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute of Child Health and Human Development National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research National Institute on Minority Health and Health Disparities National Center for Complementary and Alternative Medicine National Center on Minority Health and Health Disparities Fogarty International Center National Center for Research Resources National Library of Medicine National Institute of Biomedical Imaging and Bioengineering Clinical Center Center for Information Technology Center for Scientific Review no funding authority Different Missions, Responsibilities and Constituencies

  5. A Typical NIH Institute/Center National Advisory Council Board of Scientific Counselors Office of the IC Director Extramural Intramural Biomedical Research Contracts Biomedical Research Grants Basic & Clinical Research Clinical Trials

  6. Understanding/Navigating the NIH NIH Extramural Programs

  7. NIH Extramural Staff • Program Officer (PO) • Scientific Review Officer (SRO) • Grants Management Specialist (GMS)

  8. Program Officer A science professional, usually Ph.D./M.D. level, who: Serves as an advocate for investigators Provides scientific stewardship and administration of grants & contracts awarded by NIH Identifies areas of scientific priority and develops funding opportunities for extramural researchers Provides guidance on NIH extramural policy/procedures, research resources, and funding opportunities to extramural investigators

  9. Scientific Review Officer A science professional, usually M.D. or Ph.D. level, who: Is based at an NIH Institute or Center (IC), or at the Center for Scientific Review (CSR) Manages Study Sections and review panels for grants and contracts Selects review panel members Assigns reviewers to applications Compiles application summary statements

  10. Grants Management Specialist Business/finance professional who: Negotiates and awards all grants Provides fiscal administration of grants Is the government official on fiscal and policy issues and approvals

  11. Types of NIH Funding Opportunity Announcements (FOAs) FOA: Call for applications in a particular research area of interest to one or multiple NIH Institutes. Contracts • RFP • BAA Grants • Request for Application (RFA) • Program Announcement (PA)

  12. Types of NIH Funding Opportunity Announcements (FOAs) Request for Application (RFA) • One application receipt date • Set-aside funds • Areas of scientific interest indicated, also includes areas not supported by the RFA • Awards may have a budget cap • Programmatic, Review, and Grants Management contacts

  13. Types of NIH Funding Opportunity Announcements (FOAs) Program Announcement (PA) – 3 types • PA – general type. No set-aside funds or special review. Reviewed in standing study sections, paid with IC “payline” funds • PAR – Special review (Special Emphasis Panel) convened, no set-aside funds (paid with IC “payline” funds) • PAS – Set-aside funds, may include review by a Special Emphasis Panel

  14. When will I get my grant funded? (well, sometimes it just feels that way…)

  15. Grant Writing 101: The Big Three • Can your research move your field forward? • Is the field important – will progress make a difference in human health? • Can you and your team conduct the work (expertise, resources)?

  16. Grant Writing 101 • Read FOA instructions thoroughly • Never assume the reviewers will “know what you mean” • Refer to literature thoroughly • State rationale of proposed studies • Include well-designed tables and figures • Present an organized, clear story

  17. Common Grant Writing Mistakes • Lack of new or original ideas; incremental advances • Absence of a solid scientific rationale • Insufficient knowledge of relevant published work • Diffuse, superficial or unfocused research plan or • experimental approach • Proposed studies are too broad or too narrow • Limited/no experience in essential techniques, no collaborators with required expertise • Lack of discussion of possible pitfalls and alternative approaches • Uncertainty concerning future directions

  18. A Little Help From Your Friends • NIH extramural staff: • SRO – advice about appropriate study sections; submission requirements • PO - advice about research focus (before review), appropriate study sections, discussion of review results and applicant responses • Colleagues: read your application, well in advance of the application due date • GRIP: Grant Review for Immunologists Program • Matches new PIs with established PIs in same area • Obtain expert advice on grant application

  19. Mechanisms (Funding Opportunities) Lawrence Prograis, M.D. Division of Allergy, Immunology and Transplantation

  20. PhD Career Track and NIAID Funding Mechanisms • T32 - Institutional training grant (NRSA)-has pre- & postdoc slots • F31 - Individual (diversity) predoc fellowship (NRSA) • F31 – Individual Predoctoral Fellowship (NRSA) [FY2015 available] • F32 - Individual postdoc fellowship (NRSA) • K01- Mentored Research Scientist Award • K22 - Research Scholar Development Award • K99/R00 - Pathway to Independence Award T32 F31 T32 F32 K01 K99 R00 K22 Award Types or High School Student Graduate Student Ph.D. Faculty Position Independent Investigator Postdoc Phase Career Stage Diversity Supplements

  21. MD Career Track and NIAID Funding Mechanisms • T35 - NRSA Short Term Institutional Research Training Grant • F30 - Individual predoctoralMD/PhD and Other Dual Doctoral Degree Fellows (NRSA) • T32 - Institutional training grant (NRSA)-has pre-& postdoc slots • F32 - Individual postdoc fellowship (NRSA) • K01 - Mentored Research Scientist Award • K08 - Mentored Clinical Scientist Research Career Development Award • K23 - Mentored Patient-Oriented Research Career Development Award • K24 - Mid-Career Investigator Award in Patient-Oriented Research • K22- Research Scholar Development Award K01 K08 K23 Award Types T35 T32 F32 K24 F30 Medical Student M.D. Clinical Training Phase Research Training Phase Faculty Position Independent Investigator Diversity Supplements

  22. NIAID Fellowship Awards (Fs) F30: started FY14 • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral MD/PhD and Other Dual Doctoral Degree Fellows (Parent F30) F31 (Div): • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (Parent F31 - Diversity) F32: • Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (Parent F32) FY15: Sign on to F31: • Ruth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows

  23. Individual Fellowship Awards (Fs) • Individual awards • Cannot change the scope, move fellowship, or change mentor without prior NIH approval • NIH determines stipend levels and limited tuition reimbursement, training related expenses; F&As 8% • Review at CSR (currently 24 SS) • • Success rate < 20%

  24. NIAID Career Development Awards (Ks) K08: Mentored Clinical Scientist Research Career Development Award (Parent K08) K23: Mentored Patient-Oriented Research Career Development Award (Parent K23) K24: Midcareer Investigator Award in Patient-Oriented Research (Parent K24) K22 (PAR): NIAID Career Transition Award (K22) K99/R00: NIH Pathway to Independence Award (Parent K99/R00) NIAID supports only 1 year of a mentored phase (K99) and 2 years of the independent (R00) phase. This is a deviation from the support from all the other ICs. K01: Mentored Research Scientist Development Award (Parent K01) NIAID Career Development (K01) Awards in Epidemiology, Modeling, and Outcomes Research K25: Mentored Quantitative Research Development Award (Parent K25)

  25. Career Development Awards (Ks) • Individual awards • MDs (K08 and K23) to support development to become independent investigators • K24 (associate professor)**supports mentoring of young clinical investigators • Salary for K08/23 awards: $90K/$50K research support; F&A 8% • Most are mentored, others are not • PhDs (MDs): Mostly K22 and K99/R00: transition awards; also K01 and K25 • Review at NIAID SRP by 4 chartered committees (AIDS, AITC, MID and MID-B) • Candidate, Career Dev. Plan, Research Plan, Mentor(s), Env./Inst. Com. • Success rates about 30+%

  26. Postdoc (PhD/MD) – Should I apply for a K22 or a K99/R00? • NIAID Research Scholar Development Award (K22) • Transition award (postdoc-to-assistant professor) • 2 year award • No mentored phase. Fundable score, s/he has one year to find a position as assistant professor Phase 2: • Assistant Professor position • Own lab space • Significant start-up funds • Little teaching/ no administrative responsibilities • $150K (Year 1) + $100K (Year 2) • Success rate: >25% • NIAID’s Pathway to Independence Award (K99/R00) • Transition award (postdoc-to asst. professor) • 3 year award (other ICs 5yrs) • 1 yr mentored phase ($90K/yr) • Awardee becomes assistant professor (internal approval similar to K22 phase 2) • 2 yr independent R00 phase ($249K/yr TC) • No US citizenship required • Success rate: ca. 7-18%

  27. NIAID Transition Awards (K22 or K99/R00) Postdoc with less than 4 years of postdoc experience Assistant Professor +/- 1 year Secures a faculty Position & Submits the K22 phase II or R00 application NIAID makes the award to the new institution/candidate. Submits a K22 or K99 application and receives a fundable score

  28. Success Rates for NIAID Training and Career Grants, FY2012

  29. NIAID Training Pay lines

  30. Loan Repayment programs (LRP) • NIH wants to encourage outstanding health professionals to pursue careers in biomedical, behavioral, social, and clinical research. If you commit at least two years to conducting qualified research funded by a domestic nonprofit organization or U.S. federal, state, or local government entity, NIH may repay up to $35,000 of your qualified student loan debt per year. Loan repayment benefits are in addition to the institutional salary you receive for your research. • Clinical Research • Pediatric Research • Health Disparities Research • Contraception and Infertility Research • Clinical Research LRP for Individuals from Disadvantaged Backgrounds • General LRP site: • • A recorded overview webinar from the LRP Office:

  31. NIH WEBSITES • Training at NIH • • NIH Research Training Opportunities • • NIH Guidelines and Forms • • NIAID Advice on Training • • How to Write a Grant •

  32. Non-NIH Research Funding Websites • Fogarty International Center: • National Science Foundation (NSF): • FastLane: • Defense Advanced Research Projects Agency (DARPA) • The Congressionally Directed Medical Research Programs (CDMRP)

  33. Research Support Funding Websites • Bill and Melinda Gates Foundation: • The Wellcome Trust: • The Global Fund to Fight AIDS, Tuberculosis and Malaria: • amfAR, the American Foundation for AIDS Research: • The International AIDS Vaccine Initiative: • The Alfred P. Sloan Foundation: • Centers for Research Libraries (includes dissertations): •

  34. Private Funding Sources:(National and International) A short list of NIAID's List of Foundations and Other Funding sources at: •

  35. NIH Peer ReviewB. Duane Price, PhDSenior Scientific Review OfficerImmunology Review Branch,Division of Extramural Activities, NIAID

  36. Application Processing * CSR assigns applications to study section (review) & NIH Institute (funding) Researcher writes and Institution submits application to NIH Summary Statement and Priority Score transmitted to applicant (Commons) and NIH extramural staff Study section composed of 20-30 reviewers – review/discuss applications 3- 4 reviewers assigned to read and write critiques for each application

  37. Mock Peer Review • Sample R01 Applications and Summary Statements • NIH Grant Review Process YouTube Videos

  38. NIH Scoring Range

  39. Understanding the Summary Statement • Impact/Priority Score: 1-9 scale • Percentile: Approximate percentage of applications receiving an impact/priority score from the study section during one year (3 review cycles), NOT all types of grants receive a percentile • Resume: Official summary of review meeting discussion, for scored applications only • Critiques: Reviewers written comments

  40. What to Do After Review • Talk to your NIH Program Officer • Attends the Study Section (most cases) • Provide insights to discussion (unofficial) and possible funding options • Read the Summary Statement • Official document providing scientific merit score and summarizing reviewers comments • First paragraph (Resume) is the official summary of the meeting discussion • Strategize Next Steps • Talk to your NIH program officer again, after both of you have read the summary statement • Discuss with colleagues, mentors